Encapsulation of Small Molecules in Peptide Nanotubes Open Access

Bankston, Kornelius (2007)

Permanent URL: https://etd.library.emory.edu/concern/etds/s4655h36q?locale=en
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Abstract

The discovery of the peptide nanotube has given great optimism to the area of gene delivery systems. These structures are unique in that they were discovered from a truncated segment of Aβ(1-42). This fragment has been reported as being a critical sequence in the formation of amyloid plaques of Alzheimer's disease . The novelty of these peptide nanotubes, besides their ability to self assembly into homogeneous tubular structures, includes the self assembly of nucleobase peptide nanotubes with high specificity and localized functionality. Preliminary evidence suggests that the cytosines in the nucleobase peptide nanotube are on the surface of the single layer nanotube . The investigation of the location of the nucleobases is important in ascertaining the structure of the nucleobase peptide nanotube. To further the knowledge and versatility of this peptide sequence I discovered that small molecules interact with the nucleobase peptide nanotube.

Table of Contents

ACKNOWLEDGEMENTS

LIST OF FIGURES

LIST OF TABLES

CHAPTER 1. INTRODUCTION

References

CHAPTER 2. BILAYER STABILITY

Results and Discussion

Conclusion

References

CHAPTER 3. SMALL MOLECULE INTERACTION

Results and Discussion

Conclusion

References

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