Arsenic exposure determinants on toddlers in Arica, Chile Pubblico

Abstract

Inorganic arsenic and arsenic compounds are considered class 1 chronic non-threshold carcinogenic to humans. Long-term oral exposure to arsenic is associated with several multi-systemic health conditions. Furthermore, in utero and early-life exposures to arsenic have been linked to increased risks for several types of cancer and other diseases during adulthood. Understanding sources of early exposure is crucial to prevent detrimental health effects. Our goal was to determine whether breast milk protects toddlers from arsenic exposure and whether formula, rice consumption, drinking tap water or other dietary and environmental factors contribute to arsenic exposure in toddlers in Arica, Chile. For this secondary analysis study, we used data from a subgroup of 192 subjects from a recently completed cohort study to examine the relationship between determinants in the last 48 hours followed by urinary arsenic speciated concentration. Multivariate models were developed for each arsenic specie: arsenobetaine (AsB), arsenite (AsIII), arsenate (AsV), dimethylarsinic (DMA), monomethylarsonic (MMA) and total arsenic (excluding AsB). Our study suggests that drinking 6 or more breast milk portions protects toddlers from arsenic exposure in this population. Further, our study confirms formula, rice consumption and drinking tap water as potential source of arsenic exposure in this population and hints to other dietary and environmental modulators.

Table of Contents

Introduction 1

Methods 7

Study sample 7

Study procedures and data collection 8

Analytical methods 8

Ethical considerations 9

Statistical analysis 9

Results 12

Study participants' characteristics 12

Log-transformed arsenic species concentrations correlation 13

Toddler urinary arsenic metabolites concentration according to significant characteristics 13

Toddlers urinary arsenic metabolites concentration modelling 15

Mothers urinary arsenic metabolites concentration modelling 17

Discussion 19

Toddlers' and mothers' analyses key results 19

Strenghts and limitations 25

References 28

Tables 35

Appendix A 47

About this Master's Thesis

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School	Rollins School of Public Health
Department	Career Masters of Public Health
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Health Sciences, Epidemiology
Parola chiave	Breastfeeding Arsenic Early exposure
Committee Chair / Thesis Advisor	Steenland, Kyle, Emory University
Committee Members	Barr, Dana Boyd, Emory University
Partnering Agencies	University, college or educational institution (other than Emory)

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