Investigation of factors associated with circulating gamma-tocopherol concentrations Pubblico
Abdulla, Kennadiid (Fall 2017)
Abstract
Background: Although a- and g-tocopherol are co-consumed antioxidants, circulating g-tocopherol concentrations were paradoxically found to be inversely associated with total vitamin E intake and circulating a-tocopherol concentrations. There are limited data on this apparent paradox or on determinants of circulating g-tocopherol concentrations.
Methods: We pooled data from two outpatient, elective colonoscopy populations (pooled n=419) on whom extensive dietary, lifestyle, and medical information was collected, and the following circulating concentrations were measured: a- and g-tocopherol (via high-performance liquid chromatography), F2-isoprostanes (FiP; via gas chromatography-mass spectrometry, and high sensitivity C-reactive protein (hsCRP; via latex-enhanced immunonephelometry). Multivariable general linear models were used to assess mean g-tocopherol differences across quantiles of FiP, hsCRP, and multiple dietary and lifestyle factors.
Results: Adjusted for serum total cholesterol, mean g-tocopherol concentrations among those in the highest relative to the lowest tertiles of circulating a-tocopherol and b-carotene, a composite dietary/lifestyle oxidative balance score (higher score indicates higher antioxidant relative to pro-oxidant exposures), and total calcium and dietary fiber intakes, were -31.0% (p<0.0001), -29.0% (p<0.0001), -27.6% (p=0.0001), -29.7% (p<0.0001), and -18.6% (p=0.008) lower, respectively. For those in the highest relative to the lowest tertiles of circulating FiP and hsCRP, mean g-tocopherol concentrations were +50% (p<0.0001) and +39.0% (p<0.0001) higher, respectively.
Conclusions: These findings suggest that circulating g-tocopherol concentrations may be inversely associated with antioxidant exposures and directly associated with systemic oxidative stress and inflammation. Additional research on possible mechanisms underlying these findings and on whether circulating g-tocopherol may serve as a biomarker of oxidative stress and/or inflammation is needed.
Table of Contents
Chapter 2. Manuscript……………………………………………………………………………
Introduction……………………………………………………………………………………..1
Methods……………………………………………………………………………………...….2
Study Population……………………………………………………………………………...2
Data collection and Laboratory Analysis………………………………………………2
Statistical Analysis……………………………………………………………………………4
Results…………………………………………………………………………………………..6
Discussion……………………………………………………………………………………....8
References……………………………………………………………………………………...15
Tables…………………………………………………………………………………………..19
About this Master's Thesis
| School | |
|---|---|
| Department | |
| Subfield / Discipline | |
| Degree | |
| Submission | |
| Language |
|
| Research Field | |
| Parola chiave | |
| Committee Chair / Thesis Advisor |
Primary PDF
| Thumbnail | Title | Date Uploaded | Actions |
|---|---|---|---|
|
|
Investigation of factors associated with circulating gamma-tocopherol concentrations () | 2017-10-17 21:59:26 -0400 |
|
Supplemental Files
| Thumbnail | Title | Date Uploaded | Actions |
|---|