The effect of Alaska Native status and other underlying risk factors for chromosomal anomalies in the Alaska population from 1996-2009 公开

Abstract

Abstract

The effect of Alaska Native status and other underlying risk factors for chromosomal anomalies in the Alaska population from 1996-2009

By Cara Jane Bergo

This study examines reported chromosomal anomalies, Trisomy 13, 18 & 21, in the Alaska population from 1996-2009. Reports were used from the Alaska Birth Defects Registry and deterministically linked with birth and death certificate data from the Bureau of Vital Statistics. There were 143,781 births in Alaska during this time with 279 reported cases of chromosomal anomalies. Logistic regression was used to examine the effects of five predictors (prenatal care, alcohol/tobacco use, mother's age, region of birth) and the exposure of interest Alaska Native status on the outcome, reported chromosomal anomaly. Maternal age and region of birth were found to be significant predictors. The risk ratio for Alaska Native Status vs. Non-Native was 1.23 (95% CI=0.87, 1.74). The effect of maternal age was significant when comparing 30-34 vs. 20-29, RR=1.57 (95% CI=1.13, 2.19), 35-39 vs. 20-29 RR=2.73 (95% CI=1.94, 3.85), and 40-45 vs. 20-29 RR=10.55 (95% CI=7.45, 14.92). The effect on region of birth was significant when comparing Northern vs. Anchorage RR=1.69 (95% CI=1.02, 2.79). A sub analysis was performed to evaluate the effect among women who had late or no prenatal care, following this process there was no effect of Alaska Native Status, RR=1.07 (95% CI=0.63, 1.81).

Table of Contents

Table of Contents
Introduction...1
Methods...2
Study Population and Variables...4
Analysis...6
Results...7
Discussion...9
Strengths and Weaknesses...10
Future Directions...11
References...13
Tables...15
Figures...17

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health
关键词	Birth Defects Alaska Maternal and Child Health
Committee Chair / Thesis Advisor	Darrow, Lyndsey, Emory University
Partnering Agencies	State or local health department (not in Georgia)

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