Social and Behavioral Precursors of Conversion to Psychosis: An Investigation of Youth at Risk for Psychosis Open Access

Simeonova, Diana Iorgova (2009)

Permanent URL: https://etd.library.emory.edu/concern/etds/qz20st25n?locale=en
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Abstract

Abstract
This study explored social and behavioral problems in 122 adolescents ages 12 to 18 with
schizotypal personality disorder (SPD), other personality disorders (OPD), and non-
psychiatric controls (NC) at baseline and at one year follow-up assessments. Cross-
sectional and longitudinal examination of social and behavioral precursors of conversion
to psychosis was conducted with a subset of 14 high-risk Converted and 27 high-risk
Non-Converted adolescents. Conversion to psychosis was defined as conversion to any
Axis I schizophrenia spectrum disorder or affective disorder with psychotic features.
SPD adolescents showed a Child Behavior Checklist (CBCL) behavioral
profile with more social and behavioral impairments compared to OPD and NC
adolescents. At one year follow-up assessment, compared to the Non-Converted subjects,
the Converted subjects manifested significantly higher scores on all prodromal symptom
scales of the Structured Interview for Prodromal Symptoms (SIPS). There were no
differences in social and behavioral problems as a function of conversion status.
The findings supported the relationship between positive family history
of psychosis or affective disorders and behavioral problems, and were indicative
of constitutional vulnerability underlying the risk for psychosis. The CBCL parent-report
scale did not show promise as an alternative or adjunctive predictor of conversion to
psychosis in high-risk SPD adolescents. The findings provided support for ratings from
the SIPS structured interview as more sensitive predictors of conversion to psychosis in
high-risk SPD adolescents.

Table of Contents

Table of Contents

Introduction...........................................................1

Method.................................................................40
Results.................................................................45

Discussion.............................................................70

References............................................................85

Tables..................................................................105

Figures.................................................................116












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