Does Low Birth Weight Share Common Genetic or Environmental Pathways with Childhood Disruptive Disorders? Pubblico
Ficks, Courtney Alexandra (2010)
Abstract
Abstract
Does Low Birth Weight Share Common Genetic or Environmental
Pathways with Childhood
Disruptive Disorders?
By Courtney A. Ficks
Although advances in neonatal care over the past century have
resulted in increased rates of
survival among at-risk births, including infants with low birth
weight, we have much to learn
about the psychological outcomes in this population. In particular,
findings for associations
between birth weight and disruptive disorder symptom dimensions
(Attention-
Deficit/Hyperactive Disorder, Conduct Disorder, and Oppositional
Defiant Disorder) have been
inconsistent in the literature, and previous investigations have
failed to use genetically-
informative methods in examining low birth weight as a risk factor
for these disorders. The
current investigation examined phenotypic associations between
birth weight and symptoms
across families (using generalized linear models with generalized
estimating equations) as well
as within families (using linear and logistic regression). We then
utilized univariate and bivariate
biometric modeling to examine the extent to which associations
between low birth weight and
disruptive disorder symptom dimensions were due to common genetic
and environmental
influences. Small but significant associations between low birth
weight and several childhood
disruptive disorder symptom dimensions (inattentive, Oppositional
Defiant Disorder, and broad
externalizing symptoms) were found. Biometric models suggested that
these associations were
entirely due to common genetic influences, with no contribution of
shared and minimal
contribution of nonshared environmental risk factors. The current
study thus illustrates the
importance of using genetically-informative designs to examine
putative risk factors of child
psychopathology.
Does Low Birth Weight Share Common Genetic or Environmental
Pathways with Childhood
Disruptive Disorders?
By
Courtney A. Ficks
B.S., Arizona State University, 2007
Advisor: Irwin Waldman, Ph.D.
A thesis submitted to the Faculty of the
James T. Laney School of Graduate Studies of Emory University
in partial fulfillment of the requirements for the degree of Master
of Arts
in Psychology
2010
Table of Contents
TABLE OF CONTENTS
Introduction...2
Methods...17
Results...22
Discussion...30
Works Cited...37
Non-printed Sources...47
Tables
Table 1...48
Table 2...49
Table 3...51
Table 4...53
Table 5...55
Table 6...56
Table 7...61
Table 8...62
Figures
Figure 1...66
Figure 2...67
Figure 3...68
Figure 4...69
Figure 5...70
Figure 6...71
Figure 7...72
Figure 8...73
Figure 9...74
Figure 10...75
About this Master's Thesis
School | |
---|---|
Department | |
Degree | |
Submission | |
Language |
|
Research Field | |
Parola chiave | |
Committee Chair / Thesis Advisor | |
Committee Members |
Primary PDF
Thumbnail | Title | Date Uploaded | Actions |
---|---|---|---|
Does Low Birth Weight Share Common Genetic or Environmental Pathways with Childhood Disruptive Disorders? () | 2018-08-28 12:18:42 -0400 |
|
Supplemental Files
Thumbnail | Title | Date Uploaded | Actions |
---|