Preferential hippocampal reactivation of previous emotional events during offline consolidation Öffentlichkeit
Arun, Ankith (Spring 2022)
Published
Abstract
Background: While it has been established that emotional memories are remembered better than non-emotional memories during encoding, it remains to be seen how neural events during consolidation can further increase this disparity in retention of emotional events. The current study aimed to investigate how offline reactivation (measured as ripple activity) during sleep and non-locomotion following encoding of emotional or neutral stimuli can impact subsequent performance during the retention phase.
Methods: 6 rats were trained in a hippocampus-dependent memory task that involved affective and non-affective stimuli. Following 80 trials during the learning stage, they immediately spent 30 minutes in an isolated sleep box for the consolidation period. Their retention of the task was tested the following day.
Results: There was an overall significantly higher hippocampal ripple rate for the affective condition as opposed to the nonaffective condition. This significant difference in ripple rate was not observed in the Basolateral complex of the amygdala (BLA).
Conclusion: We predicted that both the HIP and BLA played a notable role in the consolidation of memories post encoding. However, the preliminary date suggests that the HIP could be playing a differential role in consolidation compared to the BLA. It remains to be seen if ripple activity, and more generally offline reactivation, play a significant role in the consolidation of emotional memories as opposed to non-emotional memories. With an increased sample size and increased fine-tuning of various parameters, the current trends can be better validated.
Table of Contents
I. Introduction ………………………………………………………………………………………………… 1-3
II. Method …………………………………………………………………………………………………..…. 3-4
III. Results …………………………………………………………………………………………………..….. 5-7
IV. Discussion ………………………………………………………………………………………………… 7-10
V. Diagrams and Figures ………………………………………………………………………………. 11-18
VI. References …………………………………………………………………………………………………. 19-21
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Preferential hippocampal reactivation of previous emotional events during offline consolidation () | 2022-03-31 23:12:46 -0400 |
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