Risk Factors for Isolated Total Anomalous Pulmonary Venous Return, National Birth Defects Prevention Study, 1997-2011 Open Access

Eick, Stephanie Marie (2016)

Permanent URL: https://etd.library.emory.edu/concern/etds/ng451h74s?locale=en



Risk Factors for Isolated Total Anomalous Pulmonary Venous Return, National Birth Defects Prevention Study, 1997-2011

By Stephanie Eick

BACKGROUND: Total anomalous pulmonary venous return (TAPVR) is a critical congenital heart defect. The causes of TAPVR are unknown and there is limited information on risk factors for the condition. This analysis aimed to update previous findings and examine a spectrum of risk factors for TAPVR in a large, diverse population.

METHODS: Data from the National Birth Defects Prevention Study (NBDPS) (1997-2011) were used to examine characteristics of infants with isolated TAPVR and potential associated risk factors. Multiple logistic regression was used to estimate adjusted odds ratios (OR).

RESULTS: Using data from 258 cases and 11,829 controls, we found that paternal occupation as a landscaper/groundskeeper was significantly associated with increased odds for TAPVR (aOR=2.06, 95% Confidence Interval (CI)=(1.12, 2.79)). Maternal and paternal non-Hispanic black race/ethnicity compared to non-Hispanic white were associated with decreased odds of TAPVR (aOR=0.52, 95% CI=(0.30, 0.91), aOR=0.60, 95% CI=(0.34, 0.99), respectively). One or more pregnancies was associated with increased odds of TAPVR (aOR=1.55, 95% CI=(1.14, 2.12). Borderline significant associations between prepregnancy obesity and maternal education and TAPVR were also observed.

CONCLUSION: These analyses provide support for previous reports of association between isolated TAPVR and paternal occupation as landscaper/groundskeeper. Race/ethnicity of non-Hispanic black was associated with a decreased risk of TAPVR. Mothers who had more than one previous pregnancy were at increased risk for TAPVR. Despite exhaustive efforts, the cause of isolated TAPVR remains largely unknown. A larger sample size is needed to further evaluate these relationships.

KEY WORDS: TAPVR, risk factors, NBDPS

Word Count: 246

Table of Contents

Table of Contents

Background 1

Materials and Methods 3

Study Population 3

Exposure Classification 4

Case Classification 4

Statistical Methods 6

Results 8

Discussion 10

Conclusion 13

Acknowledgements 13

Table 1 14

Table 2 17

References 19

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