Risk Factors for Isolated Total Anomalous Pulmonary Venous Return, National Birth Defects Prevention Study, 1997-2011 Open Access

Eick, Stephanie Marie (2016)

Permanent URL: https://etd.library.emory.edu/concern/etds/ng451h74s?locale=en


BACKGROUND: Total anomalous pulmonary venous return (TAPVR) is a critical congenital heart defect. The causes of TAPVR are unknown and there is limited information on risk factors for the condition. This analysis aimed to update previous findings and examine a spectrum of risk factors for TAPVR in a large, diverse population.

METHODS: Data from the National Birth Defects Prevention Study (NBDPS) (1997-2011) were used to examine characteristics of infants with isolated TAPVR and potential associated risk factors. Multiple logistic regression was used to estimate adjusted odds ratios (OR).

RESULTS: Using data from 258 cases and 11,829 controls, we found that paternal occupation as a landscaper/groundskeeper was significantly associated with increased odds for TAPVR (aOR=2.06, 95% Confidence Interval (CI)=(1.12, 2.79)). Maternal and paternal non-Hispanic black race/ethnicity compared to non-Hispanic white were associated with decreased odds of TAPVR (aOR=0.52, 95% CI=(0.30, 0.91), aOR=0.60, 95% CI=(0.34, 0.99), respectively). One or more pregnancies was associated with increased odds of TAPVR (aOR=1.55, 95% CI=(1.14, 2.12). Borderline significant associations between prepregnancy obesity and maternal education and TAPVR were also observed.

CONCLUSION: These analyses provide support for previous reports of association between isolated TAPVR and paternal occupation as landscaper/groundskeeper. Race/ethnicity of non-Hispanic black was associated with a decreased risk of TAPVR. Mothers who had more than one previous pregnancy were at increased risk for TAPVR. Despite exhaustive efforts, the cause of isolated TAPVR remains largely unknown. A larger sample size is needed to further evaluate these relationships.

KEY WORDS: TAPVR, risk factors, NBDPS

Table of Contents

Background 1

Materials and Methods 3

Study Population 3

Exposure Classification 4

Case Classification 4

Statistical Methods 6

Results 8

Discussion 10

Conclusion 13

Acknowledgements 13

Table 1 14

Table 2 17

References 19

About this Master's Thesis

Rights statement
  • Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.
  • English
Research Field
Committee Chair / Thesis Advisor
Partnering Agencies
Last modified

Primary PDF

Supplemental Files