The Development and Implementation of a Chemical Banding Program to Minimize Worker Risk Associated with the Use of Chemicals in Research Animals Open Access

Hubble, Leslie (2010)

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The Development and Implementation of a Chemical Banding Program to Minimize
Worker Risk Associated with the Use of Chemicals in Research Animals
By Leslie M. Hubble

Chemical and pharmaceutical industries have led the way in chemical risk
classification systems also known as chemical banding systems. Industry primarily uses
chemical banding for quantitative exposure monitoring. Chemical industries can approach
chemical risk management in this fashion, because they typically work with a finite number
of chemicals which often have established occupational exposure limits. In contrast,
scientific research at a University with an academic medical center can involve thousands of
chemicals, many with unknown exposure limits and unknown monitoring methods. The
frequent use of chemicals for this research can increase the relative risk and increases the
need for qualitative chemical risk assessment and mitigation. Exposure risk becomes more
difficult to assess, quantify, and control when these chemical are used animal research. The
chemicals used in animal research are typically toxic, carcinogenic, etc. and are often used to
induce or treat adverse health outcomes.
The following paper outlines a program that was designed and implemented in
conjunction with Emory University's Environmental Health and Safety Office (EHSO) and
Division of Animal Resources (DAR) to meet the intent of Occupational Health and Safety
Administration (OSHA) standards and the recommendations of Association for Assessment
and Accreditation of Laboratory Animal Care International (AAALAC). This Chemical
Banding program establishes a qualitative risk assessment method for controlling risk in the
animal facility associated with chemical research in animals. The program establishes
appropriate exposure controls to match each level of presumed risk. The program has been
implemented with such control measures as protocol approval, personnel training, and
hazard signage to identify areas where chemicals are being administered to animals.
Chemicals of unknown toxicity and nanomaterials present a challenge as the risk
associated with these materials is not well characterized. Since quantifying this risk is
resource intensive in terms of time and cost; the risk assessment and control method
presented in this document is a good foundation for mitigating the potential chemical risk to
workers in animal research.

Table of Contents

Table of Contents

Introduction Potential worker risk The challenge Chemical banding Applicability at a research university Program Design Developing Chemical Banding Levels Laboratory Practices Associated with Each Chemical Band Transforming Chemicals Bands into Animal Control Levels Exemption List Designation of Animal Control Levels & Associated Controls Program Implementation Chemical Protocols & Hazard Assessments Training program Room Hazard Signage and Cage Cards Animal Control Level 1 Program Obstacles Chemicals of unknown toxicity and nanomaterials Disposal issues Conclusions and Recommendations References

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