Dietary flavonoid intake associated with weight modulation and obesity: The REasons for Geographic and Racial Differences in Stroke (REGARDS) study Público

Abstract

Background: Obesity is a major risk factor for many chronic diseases. Evidence suggests that intake of flavonoids, which are phenolic compounds with beneficial biochemical and antioxidant effects, might contribute to weight management. This study tests the hypothesis that intakes of total and subclasses of flavonoids are inversely associated with weight gain and incident obesity in older adults.

Methods: This study included 10,443 participants from the REGARDs study, a biracial cohort of community-dwelling adults aged 45 years and older. Baseline demographic and dietary information were collected at an in-home visit. Usual dietary intake was captured by the Block98 food frequency questionnaire and flavonoid intakes were estimated based on the USDA flavonoid databases. Weights of participants were measured at baseline and follow-up approximately 10 years later. The associations between flavonoid intakes and change in weight were assessed using marginal linear models controlling for potential confounders. The associations of flavonoid intakes with incident obesity were assessed in a subset of the cohort who were not obese at baseline (n=6,627) in multivariable logistical regression models.

Results：Weight change (mean ± SD) among the total population over 10 years was -1.7 ± 9.4 kg. Higher intakes of anthocyanins and flavanones were associated with more weight loss, with a significant linear trend for flavanone. A significant inverse association for anthocyanin intakes was observed in the obesity incidence analysis (OR for the second, third, fourth and fifth quintiles were 0.95 (95% CI: 0.74, 1.21), 0.86 (95% CI: 0.67, 1.1), 0.74 (95% CI: 0.58, 0.96), and 0.7 (95% CI: 0.54, 0.9), respectively, P for trend < 0.001). This association was significant among Caucasians, but not among African Americans, in stratified analysis. No significant results were found for total flavonoids or other flavonoid subclasses.

Conclusion: This study provides some evidence that flavonoid intake might be inversely associated with weight change.

Table of Contents

TABLE OF CONTENTS

INTRODUCTION.. 1

METHODS. 4

Study population. 4

Assessment of flavonoid intake. 4

Assessment of weight change. 5

Assessment of covariates. 5

Statistical analysis. 6

RESULTS. 8

DISCUSSION.. 11

REFERENCES. 16

TABLES AND FIGURE. 18

Table 1. 18

Table 2. 20

Table 3. 21

Table 4. 22

Table 5. 23

Figure 1. 24

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Epidemiology
Palabra Clave	Obesity Weight Flavonoid
Committee Chair / Thesis Advisor	Terry Hartman, Emory University

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