An Scalable and Interoperable Real-time Software Platform for Forecasting the Onset-time of Sepsis Public

Abstract

Sepsis, a dysregulated inflammatory response to infection, is difficult to diagnose in advance of life-threatening physiological decompensations. Multiple studies have demonstrated improved outcomes when this condition is recognized and treated early. Nemati et al. have developed a real-time, high-dimensional machine learning algorithm capable of detecting sepsis four to six hours prior to clinical recognition, capable of substantially reducing the untoward effects associated with the condition. In this work, a software platform was developed that consumes live patient data, securely transports it into a cloud environment, and interprets it in real-time. Our approach leverages the benefits of cloud-based managed services that are scalable and fault tolerant. Though there are several pathways for extracting live data from electronic health records (EHR), the AIDEx platform proposed in this work is an EHR vendor-agnostic open-source solution that can be easily deployed in any clinical environments. 

Table of Contents

Introduction

Sepsis: A Health Crisis

Sepsis Prediction Algorithm

Real-time Software Platform for Forecasting the Onset of Sepsis

AIDEx: A FHIR Based Real-time Software Platform for Forecasting

the Onset of Sepsis

Overview

The AIDEx 1.0 Services

Sepsis App on Tele-ICU: A SQL Based Real-time Software Platform

at Emory Hospital for Forecasting the Onset of Sepsis

Overview of SepsisApp on Tele-ICU

Tests and Statistical methods

Conclusion and Future directions

Bibliography

About this Master's Thesis

Rights statement

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School	Laney Graduate School
Department	Computer Science and Informatics
Degree	M.S.
Submission	Master's Thesis
Language	English
Research Field	Computer Science
Mot-clé	containerization application cloud computing
Committee Chair / Thesis Advisor	Dr.Shamim Nemati, Emory University
Committee Members	Professor Ashish Sharma, Emory University Professor Babak Mahmoudi, Emory University Professor Shamim Nemati, Emory University

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