Heritability of Blood Pressure in Families from Southwest Coastal Bangladesh Pubblico
Threlkel, Ryan (Spring 2020)
Abstract
BACKGROUND
High blood pressure is a leading cause of morbidity and mortality, but it is a complex trait that can be attributed to high sodium intake, other environmental factors, and heritable genetics.
METHODS
Pedigrees were constructed with the RStudio package and were analyzed alongside phenotype data collected in a cohort study in southwest coastal Bangladesh. The pedigree and phenotype data were run in the statistical software package SOLAR-Eclipse with the pedigree variance-component linkage method, generating heritability estimates for systolic blood pressure and diastolic blood pressure for this population.
RESULTS
This analysis included 1186 individuals with both relationship and phenotype data. This included 467 first degree relationship pairs (sharing about 50% genetics), 152 second degree relationship pairs (25% shared genetics), 152 third degree relationship pairs (12.5% shared genetics), 497 relationship pairs of fourth to seventh degree, and 90 pairs classified as “Other.” However, females in these families tended to be much less related due to patrilineal marriage practices. Heritability analyses demonstrated a significant heritability value of 0.176 (SE 0.089) for unstratified DBP. Other estimates were not statistically significant, but unstratified SBP was estimated at 0.113 (SE 0.087). DBP among females was estimated at 0.439 (SE 0.280) and SBP among females was estimated at 0.131 (SE 0.302). Male SBP and DBP heritability estimates were unable to be calculated.
DISCUSSION
The differences between males and females in relatedness were unsurprising since this is a patrilineal society. However, the lack of normality among males was surprising. This could indicate inaccurate relationships in the study’s pedigree data. The only heritability estimate that was significant was overall DBP, providing evidence that among this population, about 17.6% of the variation in DBP was explained by heritable genetics.
Table of Contents
1 - BACKGROUND
2 - METHODS
2 - Study Population
2 - Data Collection Protocols
3 - Statistical Approach
4 - RESULTS
6 - DISCUSSION
6 - Strengths and Weaknesses
7 - Future Directions
8 - REFERENCES
10 - TABLES
14 - FIGURES
15 - APPENDIX: Pedigree plots of all families
About this Master's Thesis
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