Carbapenem-resistant Enterobacteriaceae (CRE) have become
an increasing public health concern, given limited treatment
options and associated high mortality. Understanding risk factors
for CRE infections of sterile sites (invasive infection) and for
mortality may have important implications for prevention. A
retrospective cohort study was performed using the Georgia Emerging
Infections Program (EIP) CRE surveillance data to evaluate risk
factors associated with invasive infection and
The study population comprised incident CRE cases from 8/2011 to 12/2015. A case required isolation, from urine or a normally-sterile site, of E. coli, Klebsiella spp., or Enterobacter spp. that was carbapenem-nonsusceptible and resistant to third-generation cephalosporins. Cases were incident if the patient resided in the surveillance area and had no prior positive cultures in 30 days, with only the first incident case for each patient included. Cases were considered invasive infection if the patient had a sterile site culture positive during the 30-day period. Mortality was defined as in-hospital mortality for admitted patients, or 30-day mortality in long-term care facility or dialysis patients. Demographic characteristics and CRE risk factor prevalence were compared using chi-square analysis between patients with sterile site versus urinary cultures positive, and patients with fatal versus non-fatal outcomes. Multivariable logistic regression was performed to evaluate whether particular risk factors were associated with invasive infection and mortality.
Of 567 CRE patients, 91 (16.0%) had an invasive infection and 476 (84.0%) had only urinary cultures positive. Central line presence, indwelling devices, and recent surgery were associated with invasive infection in multivariable analysis. The overall mortality rate was 9.0% (51/567), including 30 deaths in patients with urinary cultures positive (6.3%) and 21 deaths in patients with invasive infection (23.1%). In multivariable analysis, ICU stay, a central line, or invasive infection predicted mortality.
Device use was common and was associated with invasive infection. Patients with invasive infection and markers of severity of illness were more likely to die. Future research should focus on whether removal of unnecessary devices decreases risk of invasive infection with CRE, and whether early identification and initiation of appropriate antibiotic therapy in high-risk patients decreases mortality.
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About this Master's Thesis
|Committee Chair / Thesis Advisor|
|File download under embargo until 12 June 2019||2018-08-28||File download under embargo until 12 June 2019|