The Effect of Race on Factor VIII and von Willebrand Factor Levels After Adjustment for Covariates 公开
Payne, Amanda B. (2011)
Abstract
The Effect of Race on Factor VIII and von Willebrand Factor
Levels After Adjustment
for Covariates
By Amanda B Payne
Increased levels of Factor VIII (FVIII) and von Willebrand Factor
(VWF) have been
associated with risk of thrombosis . The proteins are acute-phase
reactants, with
levels increasing in response to physiologic stress. Levels of
FVIII and VWF have also
been associated with race. This report assesses the association of
FVIII and VWF
levels with race after adjustment for covariates associated with
factor level and race.
Data obtained from a control population from a large case-control
study were
analyzed to determine the most precise estimate of the association
of race and
factor levels. The most precise estimate of the effect of race on
FVIII levels was
determined to be a function of age, sex, CRP, fibrinogen, APTT, ABO
type, prevalent
diabetes, hormone replacement therapy use, average alcohol
consumption, and
percent of time spent sitting at work. The estimate of effect of
race after adjustment
was 0.10847 (0.07130-0.14564) ln(IU/dl). The most precise estimate
of the effect
of race on VWF levels was determined to be a function of age, sex,
fibrinogen, APTT,
ABO type, education level attainment, average alcohol consumption,
and duration of
smoking. The estimate of effect of race was
0.06745(0.02108-0.11382) ln(IU/dl).
Race remained a significant predictor of levels after adjustment
for both FVIII and
VWF models. Future studies are needed to further characterize the
association of
factor levels with race and to assess the relationship of factor
levels with risk of
thrombosis.
Table of Contents
Introduction: 1
Methods: 2
Study Population. 2
Variable Selection. 2
Demographic Variables. 3
Health-Related Variables. 3
Lifestyle Variables. 3
Laboratory Variables. 4
Statistical Analysis. 5
Results: 6
Bivariate Analyses. 6
Multivariate Analyses. 7
FVIII. 7
VWF. 9
Discussion: 10
Strengths and Limitations. 13
Future Analyses. 14
Tables: 15
Figures: 20
References: 21
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