The Effect of Race on Factor VIII and von Willebrand Factor Levels After Adjustment for Covariates 公开

Payne, Amanda B. (2011)

Permanent URL: https://etd.library.emory.edu/concern/etds/h989r3289?locale=zh
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Abstract

The Effect of Race on Factor VIII and von Willebrand Factor Levels After Adjustment
for Covariates
By Amanda B Payne
Increased levels of Factor VIII (FVIII) and von Willebrand Factor (VWF) have been
associated with risk of thrombosis . The proteins are acute-phase reactants, with
levels increasing in response to physiologic stress. Levels of FVIII and VWF have also
been associated with race. This report assesses the association of FVIII and VWF
levels with race after adjustment for covariates associated with factor level and race.
Data obtained from a control population from a large case-control study were
analyzed to determine the most precise estimate of the association of race and
factor levels. The most precise estimate of the effect of race on FVIII levels was
determined to be a function of age, sex, CRP, fibrinogen, APTT, ABO type, prevalent
diabetes, hormone replacement therapy use, average alcohol consumption, and
percent of time spent sitting at work. The estimate of effect of race after adjustment
was 0.10847 (0.07130-0.14564) ln(IU/dl). The most precise estimate of the effect
of race on VWF levels was determined to be a function of age, sex, fibrinogen, APTT,
ABO type, education level attainment, average alcohol consumption, and duration of
smoking. The estimate of effect of race was 0.06745(0.02108-0.11382) ln(IU/dl).
Race remained a significant predictor of levels after adjustment for both FVIII and
VWF models. Future studies are needed to further characterize the association of
factor levels with race and to assess the relationship of factor levels with risk of
thrombosis.

Table of Contents

Introduction: 1

Methods: 2

Study Population. 2

Variable Selection. 2

Demographic Variables. 3

Health-Related Variables. 3

Lifestyle Variables. 3

Laboratory Variables. 4

Statistical Analysis. 5

Results: 6

Bivariate Analyses. 6

Multivariate Analyses. 7

FVIII. 7

VWF. 9

Discussion: 10

Strengths and Limitations. 13

Future Analyses. 14

Tables: 15

Figures: 20

References: 21

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