Association of blood pressure with fluorescent oxidative products in a study of Whites, African Americans and West African immigrants 公开

Gong, Baoqing (2013)

Permanent URL: https://etd.library.emory.edu/concern/etds/gm80hw154?locale=zh
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Abstract

Background: Oxidative stress defined as an imbalance between pro-oxidant and anti-oxidant factors, leads to cellular damage and may cause disease. Hypertension is thought to be both caused by and result in oxidative stress. Lately, fluorescent oxidation products (FOP) were proposed as a new biomarker of oxidative stress. The purpose of this study was to examine the association between FOP and hypertension in men and women residing in the state of Georgia and representing three racial and ethnic groups: US-born Caucasians, African-Americans and West African immigrants.

Methods: The analyses used simple and multivariable linear regression models to assess the association of FOP to systolic and diastolic blood pressure (SBP and DBP, respectively) and hypertension defined as SBP140 mm Hg, or DBP90 mm Hg or self reported use of blood pressure lowering medications.

Results: In crude models, the blood pressure measures and hypertension were not associated with FOP concentrations. In the multivariable regression analysis, there was a positively and statistically significant association between FOP and SBP (β=0.0042, p=0.045) among all the participants, and in Caucasians (β=0.0075, p=0.40). In the corresponding analyses for hypertension the results were statistically significant among all participants (β=0.1407, p=0.0248) and in Caucasians (β=0.1886, p=0.0248) but not in African-Americans (β=0.2722, p=0.1462) and not in Africans (β=0.1494, p=0.1767).

Conclusion: FOP is significantly, positively associated with SBP and hypertension in the multivariate-adjusted analyses. The association seems to differ by race and ethnicity.

Table of Contents

CONTENTS

INTRODUCTION...............................................................................................................1

METHODS .....................................................................................................................4

RESULTS ......................................................................................................................9

DISCUSSION.................................................................................................................11

REFERENCES.................................................................................................................13

TABLES........................................................................................................................15

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