The Association between the Progression of Chronic Hepatitis B and
Non-virus Factors: Observational Studies of Hospitalized Chinese
Patients Open Access
Permanent URL: https://etd.library.emory.edu/concern/etds/gm80hv82s?locale=en Published
Objective:The aim of this study was
to examine the association between the changes in paired liver
biopsies and nutritional status, sleep status, alcohol consumption,
and antiviral therapy.
Methods:Data were collected from
the medical records of 190 hepatitis B patients in the 302 Military
Hospital, Beijing, China, who had two liver biopsies between
January 1999 and December 2012. Univariate analysis and
multivariate logistic analysis were conducted.
Results:69 patients (36.3%) had
improvements in fibrosis stage and 73 (38.4%) had improvements in
inflammation grade. Drinking alcohol (OR=0.35, 95%CI 0.10-1.20,
p=0.09) was a harmful factor for the progression of fibrosis.
Nutritional status, sleep status, and antiviral therapy were not
statistically associated with the improvement in fibrosis stage. In
addition, good nutritional status (OR 3.15, 95%CI 1.43-6.96,
p<0.01) and taking adefovir (OR 3.97, 95%CI 1.25-12.57, p=0.05)
were significantly associated with the improvement in inflammation
Conclusion:This study evaluated the
risk factors for the progression of liver damage and found that
alcohol consumption had a significant impact on the deterioration
of fibrosis. Nutritional status and antiviral therapy were
significantly associated with the improvement in inflammation
grade. No significant effect was associated with sleep status. The
association between the various therapeutic interventions and the
serological markers of virological clearance was not evaluated.
Without serological information, it is difficult to make any firm
conclusions. Further study will take into account whether treatment
resulted in the clearance of hepatitis B infection.
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