Comparison of maternal reports of alcohol use in pregnancy and the effect of low prenatal alcohol exposure on NEPSY executive function subtests in young children 公开

Abstract

INTRODUCTION The objectives of this study were 1) to compare maternal reports of alcohol consumption during pregnancy collected within 48 hours of delivery and 4.5 years after the birth of the child and 2) to determine relationship between low to moderate prenatal alcohol exposure and child executive function at 4.5 years of age. METHODS Population based sample consisting of 454 participants of the Fetal Growth and Development Study (FGDS) and the Follow-Up of Development and Growth Experiences (FUDGE) Study. Retrospective reports of maternal alcohol consumption during pregnancy were compared and correlated using kappa statistics. Multiple linear regression analysis was used to correlate reported alcohol consumption and child executive functioning at 4.5 years, as measured by the NEPSY Visual Attention and Statue subtests. RESULTS The greatest reporting of alcohol consumption during pregnancy occurred postpartum, with poor to fair agreement between postpartum reports and reports 4.5 years later. Children exposed to alcohol during the 2^nd or 3^rd trimester had significantly lower scores on the Visual Attention subtest at 4.5 years, scoring 18% lower than children who were not exposed in the controlled model and 19% lower in an alternative model which also controlled for age at follow-up. There was no significant association between alcohol exposure in pregnancy and performance on the Statue Test at 4.5 years. CONCLUSION Executive function deficits are seen in preschool age children who were exposed to low to moderate amounts of alcohol prenatally.

Table of Contents

Table of Contents

Chapter I: Literature Review 2

Chapter II: Manuscript 13

A. Title, Author(s), Abstract 13

B. Introduction 14

C. Methods 18

D. Results 25

E. Discussion 27

F. Tables 30

G. Appendix 35

References 38

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Health Sciences, Epidemiology Health Sciences, Obstetrics and Gynecology
关键词	PAE Prenatal Alcohol Exposure Fetal Alcohol Spectrum Disorder FASD Executive Function
Committee Chair / Thesis Advisor	Drews-Botsch, Carolyn D, Emory University
Partnering Agencies	Emory University schools, faculty or affiliated programs

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