Associations between Metabolites and Obesity: A Cross-Sectional Study in South African Adults with HIV Restricted; Files Only

Powers, Richard A. (Spring 2023)

Permanent URL: https://etd.library.emory.edu/concern/etds/fb4949719?locale=zh
Published

Abstract

Background: HIV infection puts individuals at increased risk for obesity and related chronic illnesses, and the link between specific metabolites and body mass index within this population, especially among those of African ancestry, is not well-defined. By using validated metabolites, this study aims to identify potential associations with BMI and develop targeted interventions to address health disparities in underrepresented populations.

Methods: This study conducted a cross-sectional study of 340 participants to investigate the association between metabolites and BMI. Linear regression was used to test the associations between validated metabolites and BMI while controlling for age, sex, race/ethnicity, and smoking status.

Results: Among the 154 validated metabolites, there were 20 with significant associations with BMI. 1-naphthylamine and tryptophan had the most statistically significant associations (p-value < 0.001), and phenylalanine, a replicated metabolite identified in prior studies, was also found to be highly significant (p-value = 0.004).

Discussion: The association between tryptophan and phenylalanine with BMI and obesity-related diseases may have significant public health implications as obesity is a major risk factor for a range of chronic illnesses. Future studies need to consider social determinants of health, such as food insecurity and SES, in addressing obesity-related health disparities. Further research is required to establish a concrete relationship and determine the precise association and validity of these metabolites with obesity-related outcomes.

Table of Contents

Introduction 1

Background 2

Methods 5

Results 7

Discussion 13

Conclusion 16

About this Master's Thesis

Rights statement
  • Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.
School
Department
Subfield / Discipline
Degree
Submission
Language
  • English
Research Field
关键词
Committee Chair / Thesis Advisor
Committee Members
最新修改 Preview image embargoed

Primary PDF

Supplemental Files