Incorporating Transition Metal Organometallic Chemistry into the Introductory Organic Chemistry Course Open Access

Cutrona, Kara Joy (2010)

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Over the past fifty years, transition metal organometallic chemistry has become
increasingly important in organic chemistry research. In contrast, the introductory organic
chemistry curriculum has not been sufficiently updated to reflect the significant influence
of discoveries in organometallic chemistry. To expand students' understanding of organic
chemistry, this thesis proposes an integration of transition metal organometallic chemistry
into the introductory organic chemistry course. This integration gradually builds from the
basics of organic chemistry to four important transition metal-catalyzed organic reactions:
the Heck reaction, the Suzuki reaction, olefin metathesis, and coenzyme B12-catalyzed

Table of Contents

Part 1. Introduction

1.1 Advances in Organic Chemistry
1.2 Introductory Organic Chemistry Curriculum
1.3 Problems in the Introductory Organic Chemistry Curriculum
1.4 The Psychology behind Memorization and Associations
1.5 Creating Associations within Organic Chemistry
1.5.1 Arrow Formalism
1.5.2 Integration
1.6 Objective of Thesis

Part 2. Advantages of Transition Metal Organometallic Chemistry

Part 3. Proposed Method for the Integration of Transition Metal Organometallic

3.1 Background for Introducing Transition Metals into Organic Chemistry
3.1.1 Organic Chemistry Fundamentals
3.1.2 Orbitals
3.1.3 Eighteen Electron Rule
3.1.4 Preface to Transition Metal-Catalyzed Organic Reactions
3.2 The Heck Reaction
3.2.1 The Heck Reaction in the Organic Chemistry Classroom
3.2.2 Applications

3.3 The Suzuki Reaction
3.3.1 The Suzuki Reaction in the Organic Chemistry Classroom
3.3.2 Applications
3.4 Olefin Metathesis
3.4.1 Olefin Metathesis in the Organic Chemistry Classroom
3.4.2 Applications
3.5 Coenzyme B12-Catalyzed Reactions
3.5.1 Coenzyme B12-Catalyzed Reactions in the Organic Chemistry Classroom
3.5.2 Other Coenzyme B12-Catalyzed Reactions

Part 4. Conclusion

Part 5. References

Part 6. Appendix

6.1 Recommended References for Students
6.2 Eighteen Electron Rule Problem Set

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