Feasibility of a dietary intervention with a Paleolithic diet-compatible food product Pubblico

Abstract

Objective: Previous trials of the Paleolithic diet have found improvement in metabolic and cardiovascular health indicators. We sought to evaluate the feasibility of using a pre-packaged food product compatible with the Paleolithic diet as a single-meal dietary intervention.

Methods: Healthy volunteers (n=22) replaced their midday meal with 16oz of Chuice, a bottled combination of unpasteurized, unprocessed, raw fruits, vegetables, herbs, nuts and seeds, for 14 consecutive days. The before-and-after comparisons of BMI, blood pressure, heart rate, fasting capillary blood glucose and pulse wave velocity were performed using paired t-tests and Wilcoxon related sample signed-rank tests.

Results: A total of 21 participants completed the study (95% adherence to the protocol). Pulse wave velocity decreased on average by 0.56 m/s with a 95% confidence interval between 0.00796 and 1.1063, and p values of 0.047 and 0.037 for paired t-test and Wilcoxon related samples test, respectively. There were no statistically significant differences in BMI, blood pressure, heart rate, or fasting blood glucose.

Conclusion: This pilot study suggests that the protocol is feasible, participants tolerate the intervention, and, based on preliminary findings for pulse wave velocity, a full-scale, controlled study is warranted.

Table of Contents

Background 1
Methods 4
Results 6
Discussion 8
References 11
Table 1: Ingredients and nutritional data of food product "Chuice" 16
Table 2: Baseline characteristics of study participants 17
Table 3: Outcome data for all participants completing the study 18
Table 4: Mean differences and statistical comparisons of biometric outcomes 19

About this Master's Thesis

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• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Nutrition Health Sciences, Public Health Health Sciences, Epidemiology
Parola chiave	Arterial stiffness Paleolithic diet Metabolic syndrome Chronic disease
Committee Chair / Thesis Advisor	Goodman, Michael, Emory University
Partnering Agencies	Does not apply (no collaborating organization)

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