Abstract
BACKGROUD: Humans are widely exposed to the
estrogenic/anti-androgen compound
bisphenol A (BPA) through food and drinks packaging. Numerous
studies report that
BPA alters endocrine function in animals, yet data from human
studies is limited.
OBJECTIVES: The primary aim of this study was to explore the
association between
BPA exposure and bone mineral density (BMD) in post-menopausal
women.
METHODS: We used data from the National Health and Nutrition
Examination Survey
(2005-2008), a population sample of noninstitutionalized U.S.
residents. Post-menopausal
women 50 years of age and older who completed the adult household
questionnaire and
participated in the mobile examination component were included. The
primary outcome
variable was BMD of the total hip. BMD was measured using
dual-energy X-ray
absorptiometry (DEXA). BPA concentration, the exposure, was
measured by liquid
chromatography mass spectrometry (LC-MS) in urine samples. We fit a
logistic model
with BMD, dichotomized based on the definition of the osteoporosis,
as the outcome and
quartiles of BPA as the exposure. RESULTS: The adjusted odds
ratios comparing the
upper quartiles of BPA (in ascending order) to the lowest quartile
were 1.17 (0.32-4.23),
0.88 (0.22-3.57), and 0.50 (0.12-1.99).
CONCLUSION: We found no association between urine BPA and
BMD in this cross-
sectional study.
Table of Contents
INTRODUCTION...2
BACKGROUD
Sources of BPA Exposure...3
BPA and Endocrine disruption...3
Summary of experimental animal's studies...4
Summary of BPA measured in humans...4
Osteoporosis and bone fractures...5
Race/Ethnicity...6
Menopause...6
Age...7
Body Mass Index...7
Exercise...8
Smoking...8
Alcohol consumption...9
Association between Bisphenol A exposure and bone mineral
density in post-
menopausal women, NHANES 2005-2008
ABSTRACT...10
MATERIAL AND METHODS...11
Data source...12
Study population...12
Measurement of BPA...13
Measurement of BMD...13
Measurement of confounders...13
Statistical Analysis...14
RESULTS...15
CONCLUSIONS AND DISCUSSION...16
REFERENCES...18
TABLES AND FIGURES...28
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