Association between Bisphenol A exposure and bone mineral density in postmenopausal women, NHANES 2005-2008 公开

Abstract

BACKGROUD: Humans are widely exposed to the estrogenic/anti-androgen compound
bisphenol A (BPA) through food and drinks packaging. Numerous studies report that
BPA alters endocrine function in animals, yet data from human studies is limited.
OBJECTIVES: The primary aim of this study was to explore the association between
BPA exposure and bone mineral density (BMD) in post-menopausal women.
METHODS: We used data from the National Health and Nutrition Examination Survey
(2005-2008), a population sample of noninstitutionalized U.S. residents. Post-menopausal
women 50 years of age and older who completed the adult household questionnaire and
participated in the mobile examination component were included. The primary outcome
variable was BMD of the total hip. BMD was measured using dual-energy X-ray
absorptiometry (DEXA). BPA concentration, the exposure, was measured by liquid
chromatography mass spectrometry (LC-MS) in urine samples. We fit a logistic model
with BMD, dichotomized based on the definition of the osteoporosis, as the outcome and
quartiles of BPA as the exposure. RESULTS: The adjusted odds ratios comparing the
upper quartiles of BPA (in ascending order) to the lowest quartile were 1.17 (0.32-4.23),
0.88 (0.22-3.57), and 0.50 (0.12-1.99).
CONCLUSION: We found no association between urine BPA and BMD in this cross-
sectional study.

Table of Contents

INTRODUCTION...2
BACKGROUD
Sources of BPA Exposure...3
BPA and Endocrine disruption...3
Summary of experimental animal's studies...4
Summary of BPA measured in humans...4
Osteoporosis and bone fractures...5
Race/Ethnicity...6
Menopause...6
Age...7
Body Mass Index...7
Exercise...8
Smoking...8
Alcohol consumption...9

Association between Bisphenol A exposure and bone mineral density in post-
menopausal women, NHANES 2005-2008
ABSTRACT...10
MATERIAL AND METHODS...11
Data source...12
Study population...12
Measurement of BPA...13
Measurement of BMD...13
Measurement of confounders...13
Statistical Analysis...14
RESULTS...15
CONCLUSIONS AND DISCUSSION...16
REFERENCES...18
TABLES AND FIGURES...28

About this Master's Thesis

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• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Epidemiology
关键词	Bisphenol-A bone mineral density osteoporosis
Committee Chair / Thesis Advisor	Howards, Penelope, Emory University
Partnering Agencies	Does not apply (no collaborating organization)

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