The Impact of Social Determinants on Healthcare Transition Readiness and Posttraumatic Growth Among Adolescent and Young Adult Childhood Cancer Survivors Restricted; Files Only

Kim, Gayeong (Fall 2024)

Permanent URL: https://etd.library.emory.edu/concern/etds/cj82k8561?locale=zh
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Abstract

Adolescent and young adult childhood cancer survivors (AYA CCS) experience various types of post-cancer resilience, including behavioral and emotional resilience. Social determinants of health (SDoH) (e.g., neighborhood deprivation) may influence post-cancer behavioral resilience (i.e., healthcare transition readiness) and emotional resilience (i.e., posttraumatic growth) in AYA CCS.

Manuscript I was a mixed-methods systematic review examining the impact of SDoH on healthcare transition readiness among AYA CCS. The review identified factors such as primary caregiver and AYA education levels, relationships with healthcare providers, access to health insurance and services, economic stability, neighborhood income, and parental/peer support as key contributors to healthcare transition readiness.

Manuscript II was a secondary data analysis investigating the impact of neighborhood-level SDoH on healthcare transition readiness among AYA CCS. Potential mediating and moderating effects of neuropsychological factors (e.g., posttraumatic stress and neurocognitive function) on the association between SDoH and healthcare transition readiness were also explored. The Readiness for Transition Questionnaire was used to assess the readiness with three domains: “adolescent responsibility”, “parent involvement”, and “overall readiness.” Neighborhood-level SDoH were measured by the Area Deprivation Index (ADI) and Environmental Justice Index (EJI). More deprived neighborhoods (higher ADI and EJI) were associated with greater “adolescent responsibility” and increased “parent involvement.” Posttraumatic stress mediated the relationship between ADI and adolescent responsibility, with neurocognitive function moderating the effect of ADI on posttraumatic stress. 

Manuscript III was a secondary data analysis assessing the impact of neighborhood-level SDoH on posttraumatic growth in AYA CCS. Potential mediating effects of posttraumatic stress on the relationship between SDoH and growth were also explored. Higher neighborhood deprivation was associated with increased growth. A curvilinear relationship between posttraumatic stress and growth was identified, where moderate stress is linked to increased growth, but excessive stress was associated with diminished growth. Posttraumatic stress curvilinearly mediated the relationship between neighborhood deprivation and growth, with the mediation effect varying by posttraumatic stress levels in AYA CCS.

These findings uncovered the significant impact of neighborhood-level SDoH on post-cancer resilience outcomes in AYA CCS, along with the complex influence of neuropsychological factors during the process. 

Table of Contents

INTRODUCTION

Problem Statement……………………………………………………………….….……….1

Aims of Study………………………………………………………………....……………….1

Background and Significance……………………………………………….….….……….2

Theoretical Framework………………………………………………………….….……….8

Reference………………………………………………………….….………………………...11

PAPER 1: The Impact of Social Determinants on Healthcare Transition Readiness Among Adolescent and Young Adult Childhood Cancer Survivors: A Mixed Methods Systematic Review

Abstract…………………………………………………….….….……….…….….….………22

Introduction……………………………………………….….….……….…….….….……...24

Methods……………………………………………….….….……….…….….….…….........25

Results……………………………………………….….….……….…….….….……...........28

Discussion……………………………………………….….….……….…….….….……......35

Conclusios……………………………………………….….….……….…….….….……......41

Reference……………………………………………….….….……….…….….….…….......43

PAPER 2: The Impact of Social Determinants and Neuropsychological Factors on Healthcare Transition Readiness Among Childhood Cancer Survivors

Abstract…………………………………………………….….….……….…….….….………68

Introduction……………………………………………….….….……….…….….….……...70

Research Design and Methods……………………………………………….….….………72

Results……………………………………………….….….……….…….….….……...........78

Discussion……………………………………………….….….……….…….….….……......81

Conclusion……………………………………………….….….……….…….….….…….....87

Reference……………………………………………….….….……….…….….….…….......89

PAPER 3: The Impact of Social Determinants on Posttraumatic Growth Among Adolescent and Young Adult Childhood Cancer Survivors

Abstract…………………………………………………….….….……….…….….….………108

Introduction……………………………………………….….….……….…….….….……...110

Research Design and Methods……………………………………………….….….………111

Results……………………………………………….….….……….…….….….……...........117

Discussion……………………………………………….….….……….…….….….……......119

Conclusion……………………………………………….….….……….…….….….……......124

Reference……………………………………………….….….……….…….….….……........125

CONCLUSION

Clinical Implications……………………………………………….….….……….…….…...142

Research Implications……………………………………………….….….……….…….….142

Limitations……………………………………………….….….……….…….….….……......142

Conclusion……………………………………………….….….……….…….….….…….......142

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