Legume consumption and incident sporadic colorectal adenoma risk: A pooled case-control study Pubblico

Abstract

Purpose: Legumes, especially soy, have multiple potential anti-colon carcinogenic properties. Several studies investigated associations of legumes and soy with colorectal cancer risk, but the results across the studies are inconsistent and few of the studies were conducted in a United States populations.

Methods: We conducted a pooled analysis of data from three colonoscopy-based case-control studies of incident, sporadic colorectal adenoma (pooled n=794 cases and 994 controls) conducted in Minnesota, North Carolina, and South Carolina between 1991 and 2002. Dietary intakes were assessed using semi-quantitative food frequency questionnaires.

Results: The multivariable-adjusted odds ratios (OR) with 95% confidence intervals (CI) for those in the second and third tertiles of total legume consumption relative to those in the lowest were, respectively, 1.18 (CI 0.91 - 1.51) and 1.12 (CI 0.82 - 1.53), and for soy consumption, 1.13 (0.88 - 1.47) and 0.96 (0.71 - 1.28). The ORs and 95% CIs for those above relative to those below the sex-specific median intakes of total legumes and soy in the controls were, respectively, 0.54 (CI 0.24 - 1.19) and 0.96 (CI 0.46 - 2.03) among premenopausal women and 0.89 (CI 0.54 - 1.47) and 0.68 (CI 0.41 - 1.11) among postmenopausal women who took exogenous estrogens.

Conclusion: Our findings provide no support for associations of total legume intake or soy foods intakes overall with risk for incident, sporadic colorectal adenoma, but do suggest the possibility that legume or soy intake may be inversely associated with adenomas among women with a positive estrogen status (i.e. premenopausal or taking exogenous estrogens).

Table of Contents

Background……………………………………………………………1

Manuscript……………………………………………………………12

Abstract………………………...…………..………………………...12

Introduction…………………..……………………………….…….13

Methods…………….……………………………………….………..14

Case-control studies………..……………………………………..14

Data collection……………………………………………………...16

Statistical Analysis………………………………………………...17

Results…………………………………………………………………19

Discussion…………………………………………………………....21

Reference………………………………………………………….....25

Tables……………………………………………………………….…30

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health
Parola chiave	legume colorectal adenoma
Committee Chair / Thesis Advisor	Bostick, Roberd M, Emory University

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