Evaluation of the relationship between Acne Vulgaris and Isotretinoin prescriptions amongst young adults living in Alpharetta, Georgia. Restricted; Files Only

Abstract

Acne vulgaris is a prevalent dermatological condition, particularly among adolescents and young adults. Isotretinoin, a powerful oral retinoid, has become the standard treatment for severe or recalcitrant acne, especially comedonal and nodulocystic subtypes. While generally effective, increasing evidence suggests that some patients experience persistent or recurring acne despite high-dose isotretinoin therapy. This phenomenon, often referred to as "resistant acne," has been linked to factors such as genetic predisposition, inappropriate dosing, and hormonal fluctuations. Alpharetta, Georgia—specifically the patient population served by Hamilton Dermatology—presents a unique case study, as young adults in this region are increasingly prescribed high doses of isotretinoin.

The problem addressed in this study is the rising incidence of resistant acne among individuals aged 15–25 in Alpharetta, which may be associated with isotretinoin prescription practices. The purpose of this research is to explore the prevalence of isotretinoin-resistant acne within this demographic and to assess whether elevated dosages are contributing to diminished treatment efficacy.

To investigate this issue, the study will employ a mixed-methods approach. Quantitative data will be obtained through a review of anonymized clinical records from dermatology practices in Alpharetta, focusing on isotretinoin dosages and treatment outcomes. Qualitative insights will be gathered through interviews with dermatologists at Hamilton Dermatology, aiming to understand prescribing rationales and observed patient responses. A literature review will contextualize local findings within the broader medical landscape, and statistical analyses will identify significant correlations between isotretinoin use and resistance patterns. All research activities will be

conducted in accordance with ethical guidelines, ensuring participant confidentiality and informed consent. The findings aim to inform future prescribing practices and contribute to more personalized acne treatment strategies.

Table of Contents

Table of Contents

Introduction…………………………………………………………………………………...2-5

Literature Review……………………………………………………………………………6-15

Methods……………………………………………………………………………………..15-19

Results……………………………………………………………………………………….19-23

Conclusion-.............................................................................................23-28

About this Master's Thesis

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School	Rollins School of Public Health
Department	Executive Masters of Public Health - MPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Epidemiology
Parola chiave	isotretinoin accutane dermatology skincare acne
Committee Chair / Thesis Advisor	Johnathan Alex Edwards, Emory University Madison Hamilton, Hamilton Dermatology

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