Intravenous Self-Administration (IVSA) with Psychostimulants in a Rodent Model of Depression Open Access
Lin, Sharon Jane (2011)
Abstract
Depressive symptoms and psychostimulant abuse are frequently
comorbid conditions.
The presence of both conditions in a patient makes it more
difficult to treat either one.
Despite the prevalence, there are few animal models examining
psychostimulant abuse
behaviors in depression, and none that incorporate hereditary
aspects of depression and
drug abuse. The purpose of this investigation was to examine the
intravenous self-
administration behaviors of two rat lines in fixed ratio-1 (FR-1),
progressive ratio (PR),
extinction, and reinstatement schedules. These two rat lines have
been selectively bred
for high and low activity on the forced swim test. The low active
line (Lo) is used as a
model of atypical depression, and the high active line (Hi) is said
to show a depression
resistant phenotype. Because atypical depression is the most common
depressive subtype
comorbid with drug abuse, we predicted that the Lo rats would show
higher response
rates in progressive ratio and reinstatement schedules. Instead, we
found that the Hi, or
depression resistant, rats generally responded more for both
cocaine and amphetamine
than the Lo rats in the self-administration paradigm. The Hi rats
were also found to have
a greater increase in locomotor activity than the Lo rats in
response to intraperitoneal (IP)
administration of amphetamine. These results show that
self-administration studies with
SwLo and SwHi rats using psychostimulants may be affected by
differences in baseline
activity and sensitivities of each line to the rewarding and
aversive aspects of the drug.
Table of Contents
Table of Contents
Introduction...1
Materials and Methods...4
Subjects...
Food Training...5
Surgery...5
Cocaine Self-Administration...6
Fixed Ratio-1...6
Progressive Ratio...7
Extinction...7
Drug-Primed Reinstatement...7
Amphetamine Self-Administration...8
Food Self-Administration...8
Food-Primed Reinstatement...9
Amphetamine-Induced Locomotor Activity...9
Results...10
Cocaine Self-Administration...10
Amphetamine Self-Administration...11
Food Self-Administration...12
Amphetamine-Induced Locomotor Activity...12
Discussion...13
References...23
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