Intravenous Self-Administration (IVSA) with Psychostimulants in a Rodent Model of Depression Open Access

Lin, Sharon Jane (2011)

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Depressive symptoms and psychostimulant abuse are frequently comorbid conditions.
The presence of both conditions in a patient makes it more difficult to treat either one.
Despite the prevalence, there are few animal models examining psychostimulant abuse
behaviors in depression, and none that incorporate hereditary aspects of depression and
drug abuse. The purpose of this investigation was to examine the intravenous self-
administration behaviors of two rat lines in fixed ratio-1 (FR-1), progressive ratio (PR),
extinction, and reinstatement schedules. These two rat lines have been selectively bred
for high and low activity on the forced swim test. The low active line (Lo) is used as a
model of atypical depression, and the high active line (Hi) is said to show a depression
resistant phenotype. Because atypical depression is the most common depressive subtype
comorbid with drug abuse, we predicted that the Lo rats would show higher response
rates in progressive ratio and reinstatement schedules. Instead, we found that the Hi, or
depression resistant, rats generally responded more for both cocaine and amphetamine
than the Lo rats in the self-administration paradigm. The Hi rats were also found to have
a greater increase in locomotor activity than the Lo rats in response to intraperitoneal (IP)
administration of amphetamine. These results show that self-administration studies with
SwLo and SwHi rats using psychostimulants may be affected by differences in baseline
activity and sensitivities of each line to the rewarding and aversive aspects of the drug.

Table of Contents

Table of Contents
Materials and Methods...4
Food Training...5
Cocaine Self-Administration...6
Fixed Ratio-1...6
Progressive Ratio...7
Drug-Primed Reinstatement...7
Amphetamine Self-Administration...8
Food Self-Administration...8
Food-Primed Reinstatement...9
Amphetamine-Induced Locomotor Activity...9
Cocaine Self-Administration...10
Amphetamine Self-Administration...11
Food Self-Administration...12
Amphetamine-Induced Locomotor Activity...12

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