Underlying Medical Conditions Associated with Invasive Listeriosis, United States, 1996-2014 Público

Kisselburgh, Hannah (2016)

Permanent URL: https://etd.library.emory.edu/concern/etds/9k41zf112?locale=es
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Abstract

Background. Invasive listeriosis is a rare but severe foodborne disease that is estimated to have the highest hospitalization rate and one of the highest mortality rates of all foodborne infections in the United States. Pregnant women, the elderly, and people who are immunocompromised are generally at higher risk for invasive listeriosis. However, few studies have quantified the relative risk of listeriosis for various underlying medical conditions, making targeted prevention efforts difficult.

Methods. Underlying medical conditions associated with cases of listeriosis reported to the Centers for Disease Control and Prevention during 1996 to 2014 through the FoodNet active surveillance system in 10 sites across the United States were reviewed. Overall listeriosis incidence and condition-specific incidence rate ratios were determined using published estimates of the population with each condition.

Results. During 1996 to 2014, 2,142 cases of listeriosis were reported for an overall average annual incidence of 0.24 per 100,000 people. Compared to the overall incidence, the incidence of listeriosis was estimated to be 33 times higher for people with multiple myeloma, 21 times for leukemia, 12 times for cirrhosis, and 7 times for pregnancy-associated cases.

Conclusions. Of underlying medical conditions examined, hematologic cancers conferred the highest risk of listeriosis. Targeting prevention efforts towards risk groups that have a high incidence rate ratio of listeriosis and a high incidence of the condition in the U.S. may reduce the overall incidence, morbidity, and mortality.

Table of Contents

Background 1

Methods 14

Results 17

Discussion 19

Conclusion 24

Tables and Figures 26

References 31

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