Inflammatory markers are associated with decreased psychomotor speed in patients with schizophrenia Pubblico

Abstract

Previous data have demonstrated that administration of inflammatory cytokines or their inducers leads to altered basal ganglia function associated with reduced psychomotor speed. Decreased psychomotor speed, referred to clinically as psychomotor retardation, is a core cognitive domain in patients with schizophrenia, and has been associated with poor functional outcomes. We therefore examined the cross-sectional association between plasma inflammatory markers and psychomotor speed in forty-three patients with schizophrenia. Psychomotor speed was assessed by a range of neuropsychological tests from purely motor (e.g., finger tapping tasks) to those that involve motor activity with increasing cognitive demand and cortical participation (e.g., trail making task and symbol coding task). Linear regression analyses were performed to determine the relationship of inflammatory markers and psychomotor task performance. Models were adjusted for age, race, sex, smoking status, and body mass index. Schizophrenia patients demonstrated decreased psychomotor speed on all tasks relative to published normative data from healthy controls. Interleukin-10 (IL-10) was associated with decreased performance on the finger tapping task with the non-dominant hand (b = -0.41, p = 0.012, 95% CI = -98.3, -12.79) and the trail making task (b = 0.433, p = 0.007, 95% CI = 0.123, 0.704). Soluble IL-6 receptor (sIL-6r) was associated with increased performance on the finger tapping task with the dominant hand (b = 0.395, p = 0.016, 95% CI = 0.118, 1.070). Taken together, the data indicate that a peripheral inflammatory profile including increased IL-10 and decreased sIL-6r is consistently associated with psychomotor speed in patients with schizophrenia. These data are consistent with data demonstrating that inflammation can impact basal ganglia function and indicate that tasks of psychomotor speed may be viable outcome variables in trials of anti-inflammatory therapies in schizophrenia and other neuropsychiatric disorders with increased inflammation.

Table of Contents

Introduction  1

Background   3

Methods  7

Results  11

Discussion  17

References  24

Table 1  29

Table 2 30

Table 3 31

Table 4 33

Figure 1  34

About this Master's Thesis

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School	Laney Graduate School
Department	Clinical Research
Degree	M.S.
Submission	Master's Thesis
Language	English
Research Field	Biology, Neuroscience Health Sciences, Mental Health Health Sciences, Immunology
Parola chiave	inflammation cytokine psychomotor slowing schizophrenia
Committee Chair / Thesis Advisor	Andrew Miller, Emory University
Committee Members	Matthew Magee, Emory University Erica Duncan, Emory University

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