Prevalence and Descriptive Epidemiology of Omphalocele in Iowa, 2000-2019 公开

Abstract

Abstract

 

Prevalence and Descriptive Epidemiology of Omphalocele in Iowa, 2000-2019

By Sashawn Lawrence

 

 

Background: Omphalocele is an abdominal wall defect in which all or part of the small intestine exists outside of the abdomen in a membranous sac. The epidemiology of omphalocele is not well-understood, with previous reports differing on prevalence estimates and child and parental characteristics associated with this defect. The aim of this study is to use data from a 20-year population-based sample of children with omphalocele to examine prevalence, as well as associations between omphalocele and selected child, maternal, and paternal risk factors.

Methods: For children delivered in Iowa during 2000-2019, data for children with omphalocele (n=235) were obtained from the Iowa Registry for Congenital and Inherited Disorders and for all live births and fetal deaths (n=781,113) from the Iowa Department of Public Health. These data were used to estimate omphalocele prevalence and associations with selected child, maternal, and paternal factors using log-binomial regression models. Crude and adjusted prevalence ratios and 95% confidence intervals were estimated for all case children and for those with a definite diagnosis (prenatal diagnosis and postnatal diagnosis), isolated omphalocele (no additional, major birth defect) and nonsyndromic omphalocele (no monogenic or chromosomal disorder).

Results: Prevalence (per 10,000 live births and fetal deaths) of omphalocele during 2000-2019 was 3.01 (95% confidence interval = 2.65, 3.42). The estimated annual percentage change was 1.56% per year (95% confidence interval = -0.69, 3.86). In multivariate analysis, male sex, plurality ≥ 2, advanced maternal age (≥ 35 vs. < 35 years), and other maternal race/ethnicity (vs. non-Hispanic White) were observed to be associated with an increased risk, whereas non-Hispanic Black and Hispanic maternal race/ethnicities were associated with a reduced risk. Subgroup analysis for case children with definite diagnosis and for those that presented with isolated or nonsyndromic omphalocele tended to yield similar results.

Conclusion: This is the longest temporal examination of population-based prevalence estimates for omphalocele in the US. Findings offer an increased understanding of selected child, maternal, and parental antecedents for omphalocele. Future studies with larger, more racially/ethnically diverse samples and data on additional risk factors are needed to understand the etiopathogenesis of this birth defect.

Table of Contents

Table of Contents

CHAPTER I: Public Health Significance... 1

CHAPTER II: Background and Literature Review... 3

CHAPTER III: Methods... 14

CHAPTER IV: Results... 17

CHAPTER V: Discussion... 19

REFERENCES... 22

FIGURE 1... 36

TABLE 1... 37

TABLE 2... 38

TABLE 3... 41

TABLE 4... 43

TABLE 5... 45

About this Master's Thesis

Rights statement

• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Epidemiology Health Sciences, Public Health Health Sciences, Obstetrics and Gynecology
关键词	Birth Defects Abdominal Wall Defect Omphalocele
Committee Chair / Thesis Advisor	Dr. Vijaya Kancherla, Emory University Dr. Paul Romitti, University of Iowa

最新修改

Primary PDF

Thumbnail	Title	Date Uploaded	Actions
	Prevalence and Descriptive Epidemiology of Omphalocele in Iowa, 2000-2019 ()	2022-04-21 22:30:58 -0400	Press to Select an action Download

Supplemental Files

Thumbnail	Title	Date Uploaded	Actions