Synthesis of Diphenylalanine-based Peptide Aldehydes and their Self-Assembly Propensity in a Dynamic Combinatorial Library Open Access

Zhang, Yusheng (2015)

Permanent URL: https://etd.library.emory.edu/concern/etds/7s75dc466?locale=en%5D
Published

Abstract

Small peptides with the ability to self-assemble have been investigated both for novel biomaterial discovery purposes and for origins of life research. Diphenylalanine is an example of a small peptide that have been thoroughly studied, and it has been shown to exhibit diverse self-assembly capabilities. Furthermore, chemical modifications that allow each peptide monomer to dynamically link with one another gives the peptide systems even greater possibility to form diverse structures. Inspired by previous studies in the Lynn Lab, this paper discloses the synthesis of diphenylalanine-based peptide aldehydes and discusses the various attributes of the dynamic combinatorial library (DCL) established using the diphenylalanine based peptide aldehydes.

Table of Contents

Introductions 8

Part 1: Synthesizing the Peptides

I. Coupling Amino Acids 15

II. Efforts in procuring Homoserine 17

III. Synthesis, purification, and protection of peptide aldehydes 20

IV. Fmoc removal and further purifications 23

Part 2: Establishing and Characterizing the DCL 25

Conclusion 33

References 35

About this Honors Thesis

Rights statement
  • Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.
School
Department
Degree
Submission
Language
  • English
Research Field
Keyword
Committee Chair / Thesis Advisor
Committee Members
Last modified

Primary PDF

Thumbnail Title Date Uploaded Actions
Synthesis of Diphenylalanine-based Peptide Aldehydes and their Self-Assembly Propensity in a Dynamic Combinatorial Library () 2018-08-28 10:09:41 -0400

Supplemental Files

Thumbnail Title Date Uploaded Actions