The Associations between PFOA, PFOS and Cholesterol Levels in US Pregnant Women: NHANES 2003-2006 公开

Abstract

Background: Perfluorooctanoic acid (PFOA) and perfluorooctane sulfate (PFOS) are two of the most studied types of perfluoroalkyl compounds which have been widely used in assorted consumer and industrial products. Several epidemiologic studies have shown positive statistically significant associations between PFOA and cholesterols as well as between PFOS and cholesterols, which may result in various adverse health effects. However, such associations during pregnancy may be different.

Methods: A cross-sectional study was performed on 174 pregnant women participating in the 2003-2006 National Health and Nutrition Examination Survey (NHANES). PFOA, PFOS and cholesterols (total cholesterol, high-density lipoprotein [HDL] and low-density lipoprotein [LDL]) were measured in serum. Linear regression was performed to determine the associations between PFOA, PFOS and cholesterol levels.

Results: A significant positive association between PFOS and LDL was found (p < 0.05), while the associations between PFOA and cholesterols as well as between PFOS and non-LDL cholesterols were not significant (p > 0.05). One ln-ng/mL increase in PFOS was associated with 21.0 (95% CI: 0.6, 41.4) increase in LDL, adjusting for age, race, education level, annual family income, BMI, total fat intake, serum cotinine, month of pregnancy and number of former pregnancies as confounders.

Conclusion: We observed little evidence that PFOA and PFOS affect cholesterol levels during pregnancy, with the possible exception of the effect of PFOS on LDL. However, since PFCs have been associated with other adverse health effects including pregnancy-induced hypertension and low birth weight, controlling the exposure to PFOA and PFOS is still highly necessary for pregnant women.

Table of Contents

Background.....................................................................................................................................1 Methods..........................................................................................................................................7

Data Source and Study Population.....................................................................................................7

Measurement of Exposure and Outcome ...........................................................................................8 Covariates.......................................................................................................................................9

Statistical Analysis.........................................................................................................................10 Results..........................................................................................................................................14

PFOA and cholesterol levels............................................................................................................16

PFOS and cholesterol levels............................................................................................................17 Discussion.....................................................................................................................................19

Strengths and Weaknesses .............................................................................................................21

Future Directions...........................................................................................................................22 References....................................................................................................................................24 Tables...........................................................................................................................................31 Appendices...................................................................................................................................36

Appendix I: Additional Tables for Model Selection...........................................................................36

Appendix II: SAS Code...................................................................................................................44

About this Master's Thesis

Rights statement

• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Environmental Health Health Sciences, Epidemiology
关键词	perfluoroalkyl compounds cholesterol levels chemical exposure reproductive health environmental epidemiology pregnant women
Committee Chair / Thesis Advisor	Darrow, Lyndsey, Emory University

最新修改

Primary PDF

Thumbnail	Title	Date Uploaded	Actions
	The Associations between PFOA, PFOS and Cholesterol Levels in US Pregnant Women: NHANES 2003-2006 ()	2018-08-28 12:35:09 -0400	Press to Select an action Download

Supplemental Files

Thumbnail	Title	Date Uploaded	Actions