Prevalence and Descriptive Epidemiology of Congenital Hydrocephalus in Iowa, 2003-2011 Public

Abstract

Background: There is a paucity of contemporary information on the prevalence of congenital hydrocephalus (CH) and associated factors in the United States (US). We conducted a retrospective study using data from a Midwestern birth cohort to examine prevalence and descriptive epidemiology of CH.

Methods: We used population-based, surveillance data from the Iowa Registry for Congenital and Inherited Disorders to compare CH cases (n=244) with Iowa live births (n=353,805) delivered during 2003–2011. Cases were classified as isolated (no additional major birth defects) or multiple (one or more additional major birth defects). We used Poisson regression analysis to estimate prevalence per 10,000 live births and logistic regression analysis to estimate crude and adjusted prevalence ratios (cPRs and aPRs, respectively) and corresponding 95% confidence intervals (CI)s; aPRs were controlled for selected infant and parental characteristics.

Results: Overall, 83 (34%) of 244 cases were isolated. Among all cases, CH prevalence was 6.9 (95% CI=6.1,7.8). In crude analyses, we observed positive associations for males, plural pregnancies, and parental age at delivery (<20 or ≥35 years) and race/ethnicity; estimates for plural pregnancies and paternal race/ethnicity had CIs that excluded the null. Where data were available, findings were similar for isolated and multiple CH cases.

Conclusion: Our estimated CH prevalence in Iowa is comparable to other regions of the US. Our findings for some, but not all, infant and parental characteristics were comparable to previous findings. Future studies are needed to confirm prevalence patterns and associated factors among CH phenotypes.

Table of Contents

1 | INTRODUCTION.....................................................................................................5

2 | METHODS .............................................................................................................8

2.1 | Human subjects approval..........................................................................................8

2.2 | Case enumeration and classification..........................................................................8

2.3 | Birth data .................................................................................................................8

2.4 | Infant and parental characteristics ............................................................................9

2.5 | Prevalence analysis...................................................................................................9

2.6 | Descriptive analysis ................................................................................................10

3 | RESULTS..............................................................................................................10

3.1 | Prevalence analysis.................................................................................................10

3.2 | Descriptive analysis ................................................................................................11

4 | DISCUSSION ........................................................................................................12

REFERENCES .............................................................................................................16

TABLES .....................................................................................................................20

FIGURES ...................................................................................................................25 

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Global Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Health Sciences, Epidemiology
Mot-clé	POPULATION SURVEILLANCE PREVALENCE RISK FACTORS EPIDEMIOLOGY CONGENITAL HYDROCEPHALUS
Committee Chair / Thesis Advisor	Vijaya Kancherla, Emory University

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