The Role of the Hippocampus in the Development of Spatial Memory Público

Blue, Shala Natasha (2009)

Permanent URL: https://etd.library.emory.edu/concern/etds/6t053g573?locale=es
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Abstract

Previous studies have suggested that the protracted development of certain spatial
memory processes in primates may be correlated with the protracted neural maturation of
the hippocampus. However, due to a lack of evidence in non-human primates regarding
normal structural and functional maturation of the hippocampus, the present study
investigated whether: 1) hippocampal-dependent spatial memory had a protracted
development, 2) early damage to the hippocampus resulted in delayed impairments in
spatial memory that correspond to the timing at which the hippocampal-dependent spatial
memory abilities emerge, and 3) the effects of early damage to the hippocampus
mimicked the effects of adult damage or whether significant sparing of spatial memory
functions occurred after the neonatal hippocampal lesions. Rhesus macaque monkeys
that received neonatal ibotenic acid lesions of the hippocampus (N=5) and controls
(N=6), were tested on two versions of a VPC paradigm measuring spatial location
memory and object-place associations at 8-months, 18-months and 5-6 years.
Performance was evaluated throughout development and adult performance of animals
with neonatal hippocampal lesions was compared to the performance of animals with
adult lesions of the hippocampus, using the same paradigm, from a previous study. We
found evidence for a protracted development of spatial memory abilities in normally
developing rhesus monkeys with regards to both spatial location and object-place
association. In addition, we found that animals with bilateral neonatal hippocampal
lesions did not show a preference for novelty throughout development and that their
performance as adults was similar to animals with bilateral adult lesions.

Table of Contents

CHAPTER 1. INTRODUCTION.................................................................. 1
CHAPTER 2. METHODS......................................................................... 18
CHAPTER 3. RESULTS & DISCUSSION (NORMAL DEVELOPMENT).................... 29
CHAPTER 4. RESULTS & DISCUSSION (EARLY HIPPOCAMPAL AMAGE)............. 47
CHAPTER 5. RESULTS & DISCUSSION (TIME OF DAMAGE)............................ 76
CHAPTER 6. GENERAL DISCUSSION.......................................................... 89
REFERENCES....................................................................................... 92

LIST OF FIGURES AND TABLES
TABLE 1. VIEWING BEHAVIORS AND NOVELTY PREFERENCE IN SHAM-OPERATED

ANIMALS............................................................................................ 30-31
TABLE 2. PERCENT DAMAGE FOR MEMBERS OF GROUP NEO-H-IBO................. 48
TABLE 3. VIEWING BEHAVIORS AND NOVELTY PREFERENCE IN ANIMALS WITH
NEONATAL HIPPOCAMPAL LESIONS.......................................................... 52-53
TABLE 4. INTENDED DAMAGE TO THE HIPPOCAMPAL FORMATION AND
UNINTENDED DAMAGE TO ADJACENT AREAS.............................................. 77

FIGURE 1. NEUROANATOMY OF THE PRIMATE HIPPOCAMPUS....................... 6-7
FIGURE 2. SPATIAL AND NON-SPATIAL VISUAL PAIRED COMPARISON (VPC)
TASKS............................................................................................... 23-24
FIGURE 3. NOVELTY PREFERENCE IN VPC TASKS....................................... 33-34
FIGURE 4. NOVELTY PREFERENCE IN THE VPC-OBJECT-IN-PLACE AND VPC-
OBJECT-CONTROL TASKS...................................................................... 36
FIGURE 5. REPRESENTATIVE CASE NEO-H-IBO 4....................................... 50
FIGURE 6. NOVELTY PREFERENCE IN VPC-SPATIAL-LOCATION TASK............. 55
FIGURE 7. BETWEEN GROUP DIFFERENCES IN NOVELTY PREFERENCE IN THE
VPC-SPATIAL-LOCATION TASK.............................................................. 57
FIGURE 8. NOVELTY PREFERENCE IN THE VPC-OBJECT-IN-PLACE TASK......... 59
FIGURE 9. BETWEEN GROUP DIFFERENCES IN NOVELTY PREFERENCE IN THE
VPC-OBJECT-IN-PLACE TASK................................................................. 61
FIGURE 10. NOVELTY PREFERENCE IN THE VPC-OBJECT-CONTROL TASK....... 63
FIGURE 11. NOVELTY PREFERENCE IN THE VPC-OBJECT-IN-PLACE AND
VPC-OBJECT-CONTROL TASKS IN ANIMALS WITH BILATERAL HIPPOCAMPAL

LESIONS............................................................................................ 64
FIGURE 12. EXTENT OF LESION............................................................. 78-79
FIGURE 13. NOVELTY PREFERENCE IN VPC-SPATIAL-LOCATION (A) AND
VPC-OBJECT IN PLACE (B) TASKS........................................................... 82-83





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