Night shift work and alteration in leucocyte levels: A meta-analysis Open Access

Fan, Shaoqi (2016)

Permanent URL: https://etd.library.emory.edu/concern/etds/6h440t030?locale=en
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Abstract

Objectives . Objectives. Though night shift work has been studied in relation to various diseases, there has yet to be any systematic review or meta-analysis indicating how long-term and short-term night shift works affect the immune system on the cellular level. This meta-analysis aimed to synthesize the effect of sleep disturbance from long-term and acute short-term night shift work implementing on total leucocyte count.

Methods . Searching strings comprised of MeSH terms and keywords were developed. PubMed, EMBASE, Web of Science databases were searched with different searching logics. Inclusion and exclusion criteria were determined in selecting eligible references. A PRISMA flow diagram visualized both the screening and selection processes.

Results . Out of total 486 searched references, twelve were determined eligible--five were cross-sectional studies and the other seven were experimental studies. Only four studies include female as study subjects, and the total number of male subjects was greater than that of female subjects. Definition of night shift work or sleep deprivation/restriction were various across studies. Studies were grouped into two subgroup meta-analyses: i) five cross-sectional studies; ii) five cross-sectional studies plus two experimental studies which provide between-subjects measurements. The overall effects from the results showed that total leucocyte counts among night shift workers or sleep deprivation/restriction groups were significantly higher.

Conclusions . Chronic sleep disturbance could activate the systemic immunization and elevate peripheral total leucocyte count. This effect might be intensified when sleep disturbance was acute and short-term. No significant heterogeneity was found among studies included into the meta-analyses. Further studies are needed to investigate the mechanism of how the interaction between on-site occupational exposures and night shift work affect the immune system.

Table of Contents

Table of Contents Introduction........................................................................................................................... 1 Method................................................................................................................................. 3 Results................................................................................................................................ 14 Discussion............................................................................................................................ 24

Conflict of interest statement.................................................................................................. 25

Acknowledgements................................................................................................................ 25 Appendix............................................................................................................................. 25 Reference............................................................................................................................ 30

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