Night shift work and alteration in leucocyte levels: Ameta-analysis Open Access

Abstract

Objectives. Objectives. Though night shift work has been studied in relation to various diseases, there has yet to be any systematic review or meta-analysis indicating how long-term and short-term night shift works affect the immune system on the cellular level. This meta-analysis aimed to synthesize the effect of sleep disturbance from long-term and acute short-term night shift work implementing on total leucocyte count.

Methods. Searching strings comprised of MeSH terms and keywords were developed. PubMed, EMBASE, Web of Science databases were searched with different searching logics. Inclusion and exclusion criteria were determined in selecting eligible references. A PRISMA flow diagram visualized both the screening and selection processes.

Results. Out of total 486 searched references, twelve were determined eligible--five were cross-sectional studies and the other seven were experimental studies. Only four studies include female as study subjects, and the total number of male subjects was greater than that of female subjects. Definition of night shift work or sleep deprivation/restriction were various across studies. Studies were grouped into two subgroup meta-analyses: i) five cross-sectional studies; ii) five cross-sectional studies plus two experimental studies which provide between-subjects measurements. The overall effects from the results showed that total leucocyte counts among night shift workers or sleep deprivation/restriction groups were significantly higher.

Conclusions. Chronic sleep disturbance could activate the systemic immunization and elevate peripheral total leucocyte count. This effect might be intensified when sleep disturbance was acute and short-term. No significant heterogeneity was found among studies included into the meta-analyses. Further studies are needed to investigate the mechanism of how the interaction between on-site occupational exposures and night shift work affect the immune system.

Table of Contents

Introduction.................................................................................................................1

Method........................................................................................................................3

Results........................................................................................................................14

Discussion...................................................................................................................24

Conflict of interest statement........................................................................................25

Acknowledgements.......................................................................................................25

Appendix.....................................................................................................................25

Reference.....................................................................................................................30

About this Master's Thesis

Rights statement

• Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.

School	Rollins School of Public Health
Department	Environmental Health
Degree	MPH
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Public Health Health Sciences, Occupational Health and Safety Environmental Sciences
Keyword	Sleep deprivation Night shift work Sleep restriction Total leucocyte count Meta-analysis
Committee Chair / Thesis Advisor	Steenland, Kyle, Emory University
Committee Members	Tolbert, Paige, Emory University

Last modified

Primary PDF

Thumbnail	Title	Date Uploaded	Actions
	Night shift work and alteration in leucocyte levels: Ameta-analysis ()	2018-08-28 13:34:15 -0400	Press to Select an action Download

Supplemental Files

Thumbnail	Title	Date Uploaded	Actions