The Correlation between Life Quality of Female Patients with Cystic Fibrosis and Vitamin D Level 公开

Abstract

Abstract

Importance

Vitamin D deficiency occurs frequently in patients with cystic fibrosis often due to pancreatic exocrine insufficiency and lack of outdoor activity. However, previous research showed that vitamin D deficiency is associated with an increase in the risk of health issues such as cancer, osteomalacia, and rickets. Investigating the correlation between vitamin D levels in females with cystic fibrosis and their life quality might improve their daily lives.  

Objective

To determine if there is a positive correlation between vitamin D status in female patients with cystic fibrosis and their life quality, sexual function, and mobility.

Design/Setting

Quantitative Studies using Survey and Data from Blood Samples

Participants

26 consented women with cystic fibrosis, aged between 16-50 years, who were treated at Children’s Hospital of Atlanta, Emory Clinic, and Emory Hospital from January 1, 2000, to August 10, 2018. Participants should be patients who are not in critical condition, on steroids, and post-liver or lung transplantation.

Measure

25-hydroxyvitamin D Concentration using 25 VitD^s, an FDA-cleared and CE-marked machine that uses an automated Chemiluminescence Immunoassay (CLIA) format. 3 surveys that each measures different criteria: quality of life, female sexual function, and mobility.

Results

Unfortunately, there was no significant difference between vitamin D status and life quality scores, sexual activity scores, and mobility scores of female patients with cystic fibrosis. In other words, we did not find any correlation between the vitamin D status and life quality scores, sexual activity scores, and mobility scores of female patients with cystic fibrosis.

Conclusion and Relevance

We reported that vitamin D status is unlikely to have a correlation between the life quality, sexual activity, and mobility of female patients with cystic fibrosis.

Table of Contents

Table of Contents

Abstract……………………………………………………………………………………….1 Introduction and background……………………………………………………………….3

Materials and Methods…………………………………………………………………...…5

Results…………………………………………………………………………….................7

Discussion………………………………………………………………………..……….....11

Conclusion…………………………………………………………………………...………15

Tables and Figures………………………………………………………………….………16

           Table 1: Participants Baseline Demographics by Vitamin D Status

           Table 2: Statistical Comparison between group’s CFQ-R score

           Figure 1: Difference in CFQ-R score of each vitamin D level Group

           Table 3: Statistical Comparison between group’s FSFI-6 score

           Figure 2: Difference in FSFI-6 score of each vitamin D level Group

           Table 4: Statistical Comparison between group’s LSA score

           Figure 3: Difference in LSA score of each vitamin D level Group

About this Honors Thesis

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School	Emory College
Department	Biology
Degree	B.S.
Submission	Honors Thesis
Language	English
Research Field	Biology, General
关键词	vitamin D life quality cystic fibrosis
Committee Chair / Thesis Advisor	Vin Tangpricha, Emory University
Committee Members	Arbilly Michal, Emory University William Hunt, Emory University

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