T cell receptor affinity controls activation of competing CD4 T cells Open Access

Jahng, Emil Albert (2016)

Permanent URL: https://etd.library.emory.edu/concern/etds/6969z103j?locale=en
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Abstract

The immune system comprises many different types of cells. One class of cells, CD4 T cells, helps coordinate cell-mediated immune responses through binding interactions between their T cell receptors and antigenic peptide-MHC II complexes displayed on antigen presenting cells. Since each CD4 T cell is unique and has a stochastically generated T cell receptor, a host's population of CD4 T cells has a range of affinities for any given peptide-MHC II complex. Moreover, it has been shown that during an immune response, CD4 T cells with both high and low affinities for antigen can proliferate, with low affinity CD4 T cells displaying delayed proliferation compared to higher affinity cells. However, it is not known why this is the case. Here, we explore the interactions between high and low affinity CD4s with the hypothesis that high affinity CD4 T cells can help low affinity CD4 T cells proliferate. Our results provide evidence that these cells compete for access to activating factors on the surface of antigen-presenting cells. These results are consistent with others in demonstrating that competition can occur between T cells. Further investigation of such interactions may hopefully lead to a better understanding of the importance of the presence of low and high affinity CD4 T cells during a polyclonal helper T cell response.

Table of Contents

Title 1

Abstract 1

Introduction 1

Methods 4

Results 8

Discussion 16

Conclusion 18

References 18

Figure 1 8

Figure 2 11

Figure 3 13

Figure 4 14

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