Is Heart Rate Variability Related to Memory Performance in Middle Aged Men? Public
Shah, Amit Jasvant (2011)
Published
Abstract
Is Heart Rate Variability Related to Memory Performance in
Middle Aged Men?
By Amit Shah
OBJECTIVE: Heart rate variability (HRV), a measure of
autonomic function, has been
associated with cognitive function, but studies are conflicting.
Previous studies have also
not controlled for familial and genetic influences.
METHODS: We performed power spectral analysis on 24-hour
ambulatory ECG's in 416
middle-aged male twins from the Vietnam Era Twin Registry. Memory
and learning were
measured by verbal and visual selective reminding tests (SRT).
Mixed-effect regression
models were used to calculate associations between and within twin
pairs, while
adjusting for covariates.
RESULTS: The mean age ± SD was 55 ± 2.9 years. A
statistically significant positive
association was found between measures of HRV and verbal, but not
visual, SRT
scores. The most statistically significant unadjusted association
was found between very
low frequency (VLF) HRV and verbal total recall SRT, such that each
natural logarithm
of increase in VLF was associated with an increased verbal SRT
score of 4.85 points
(p=0.002). The association persisted despite adjustment for
demographic and
cardiovascular risk factors, and after accounting for familial, and
genetic factors by
comparing twins within pairs. A significant interaction was found
between post-traumatic
stress disorder (PTSD) and HRV, such that total power and ultra low
frequency were
associated with SRT in twins (n=362) without PTSD, but not in those
with PTSD.
CONCLUSION: In conclusion, lower frequency spectra of HRV
are associated with
verbal, but not visual, learning and memory, particularly in
subjects without PTSD. This
association may highlight mechanisms of cognitive dysfunction and
have implications on
prevention and therapy of cognitive decline.
Table of Contents
TABLE OF CONTENTS
Introduction
.............................................................1
Background..............................................................3
Methods
..................................................................8
Results
..................................................................18
Discussion..............................................................21
References.............................................................25
Figure 1
.................................................................30
Figure 2
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Figure 3
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Figure 4
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Figure 5
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Table 1
..................................................................35
Table 2
..................................................................36
Table 3
..................................................................37
Table 4
..................................................................38
Table 5
..................................................................39
Table 6
..................................................................40
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