The Impact of Body Mass Index (BMI) on the Safety and Outcomes of Small Molecule Inhibitors (SMI) in Gastrointestinal Cancer, Lung Cancer, and Renal Cell Carcinoma Pubblico

Abstract

Nowadays more and more people are facing the health issue “obesity”. Usually, people would consider obesity as a risk factor to health. However, scientists found that obesity improved the survival of patients with cancer, which is called “obesity paradox”. This is a mutrual component in cardio-metabolic literature, but less in oncology. To identify the association between BMI and the treatment effect of Small Molecule Inhibitors (SMI) in gastrointestinal cancer, lung cancer, and renal cell carcinoma. We conducted a single center, retrospective study at Winship Center. We found that overall survival of patients are worse for low-weight patients compared with patients with high BMI during later period of these diseases, gastrointestinal cancer, lung cancer, and renal cell carcinoma. Overall survival of patients had adverse events were significantly shorter than patients had no adverse events.

Table of Contents

1. INTRODUCTION.... 2

2. METHODS.... 3

2.1 STUDY DESIGN.... 3

2.2. DATA COLLECTION....4

2.3. PARTICIPANT SELECTION.... 4

2.4. GENERALIZED STRATIFICATION MECHANISM.... 5

2.5. OUTCOME OF INTEREST..... 5

2.6. STATISTICAL ANALYSIS..... 6

3. RESULTS. 7

TABLE 1 DESCRIPTIVE STATISTICS..... 7

TABLE 2 UNIVARIATE ASSOCIATION WITH BMI ....8

TABLE 3 UNIVARIATE ASSOCIATION WITH PFS....9

TABLE 4 MULTIVARIABLE SURVIVAL ANALYSIS OF PROGRESSION FREE SURVIVAL.... 10

FIGURE 1 PROGRESS FREE SURVIVAL (PFS) CURVES BY BMI.... 11

TABLE 5 UNIVARIATE OS ANALYSIS.... 12

TABLE 6 MULTIVARIATE ASSOCIATION OVERALL SURVIVAL ANALYSIS.... 14

FIGURE 2 OVERALL SURVIVAL CURVES BY BMI.... 15

TABLE 7 MULTIVARIABLE LOGISTIC REGRESSION WITH OUTCOME = ADR.... 16

4. CONCLUSION.... 17

5.DISCUSSION.... 19

REFERENCES....20

About this Master's Thesis

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School	Rollins School of Public Health
Department	Biostatistics
Subfield / Discipline	Biostatistics - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Biology, Biostatistics
Parola chiave	Obesity BMI Oncology
Committee Chair / Thesis Advisor	Zhengjia, Chen, University of Illinois at Chicago
Committee Members	Michael, Haber, Emory University

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