Interpregnancy Interval and Autism Spectrum Disorders among California Siblings in the CHARGE Study Público
Hutchings, Isabelle Anna (2014)
Abstract
Background
Autism Spectrum Disorders (ASDs) have a significant health burden
characterized by deficits in social skills and communication,
repetitive behaviors, and stereotyped body movements usually
beginning in early childhood. Short interpregnancy interval
(≤ 12 months) has been associated with an increased risk of
Autism Spectrum Disorders (ASDs) in previous birth-registry studies
of sibling pairs. These studies, however, had limited ability to
adjust for potential confounders.
Methods
ASDs were measured among California-born, singleton, full-sibling
pairs in a case-control study. General population controls were
selected from California birth files using stratified random
sampling. Trained researchers collected information for index
children for ASDs diagnoses using the Autism Diagnostic
Interview-revised (ADI-R) and the Autism Diagnostic Observation
Schedules (ADOS). They also used a variety of in-person and
phone-based interviews to collect information on potential
confounders from the index children's primary caregivers.
Interpregnancy interval was defined as the time between the birth
of a prior child and the conception of the index child in a full
sibship. It was calculated based on information collected during
interviews with the primary caregiver of the index child. Odds
ratios were estimated by fitting logistic regression models.
Results
This study included 499 singleton, full sibling pairs born in
California, 265 cases and 234 controls. The OR for ASDs in the
index child comparing IPI ≤ 12 months adjusting for mother's
age at conception of the index child, race, education, marital
status, birthplace, desire to get pregnant, procedures used to
conceive the index child, prenatal vitamin use in the first month
of pregnancy of the index child, family home ownership, child's
gender and preterm birth was 2.0 (95% CI 1.2-3.6).
Conclusions
This analysis found an increased odds of ASDs among births ≤
12 months apart, consistent with previous studies. Due to the
extensive data gathered by interviewing primary caregivers, this
study was able to control for a variety of potential confounders
that had not previously been examined.
Table of Contents
Chapter One...3
Introduction and Background...3
ASDs...3
IPI...8
IPI and ASDs...9
Chapter Two...12
Introduction...12
Methods...13
Results...15
Discussion...16
References...19
Table 1...22
Table 2...24
Appendix A. IRB Letter of Approval...25
About this Master's Thesis
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Primary PDF
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Interpregnancy Interval and Autism Spectrum Disorders among California Siblings in the CHARGE Study () | 2018-08-28 14:45:59 -0400 |
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Supplemental Files
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Table 2.docx () | 2018-08-28 14:49:00 -0400 |
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