Association between Anti-Inflammatory Interleukin-10 and Executive Function in African American Women at risk for Alzheimer's Disease translation missing: zh.hyrax.visibility.files_restricted.text

Patel, Ruhee (Spring 2019)

Permanent URL: https://etd.library.emory.edu/concern/etds/47429b148?locale=zh
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Abstract

Significance: The prevalence of AD differs by race: African-Americans (AAs) are two to four times more likely to be diagnosed with AD than non-Hispanic whites. AAs with elevated biomarkers of Alzheimer’s Disease (AD), i.e., amyloid beta (Aβ) deposition, exhibit greater neurodegeneration in AD signature regions compared to non-Hispanic whites with elevated Aβ deposition (McDonough, 2017).

Objective: This thesis aims to examine whether inflammatory levels of interleukin-10 are associated with performance on executive function in 31 African American women at risk for developing AD because of parental history factors.

Design: Observational study comparing groups with elevated and normal interleukin-10 levels.

Participants: Study included 31 African-American women (age = 58.9 ± 8 years) with parental history of AD.

Measures: Inflammatory serum biomarkers and cognitive tests including Montreal Cognitive Assessment, Tower of London Test, Trail-Making Test, Timed Up and Go Test, and Color-Word Interference Test.

Results: Performance on Trail-Making Test differed between the elevated interleukin-10 group and the normal interleukin-10 group, with the elevated interleukin-10 group showing worse performance. There were no significant differences between groups on Tower of London Test, Timed Up and Go Test, Montreal Cognitive Assessment, and Color-Word Interference Test. There were significant differences between groups in levels of other inflammatory markers, including Interleukin-7 and interleukin-9 and interferon γ.

Conclusions: Although the exact relationship between AD and inflammation is not well defined, certain interleukins and cytokines, which also have genetic components, may incite inflammation and neuronal degradation (Weisman et al., 2006), leading to impaired aspects of executive function, e.g, set switching and inhibition. Further research should be conducted to continue investigating the relationship between inflammation, AD, and cognitive function.

Table of Contents

Introduction……………………………………………………………………..……………..1-9

Methods…………………………………………………………………………………..…10-14

Results………………………………………………………………………………………15-16

Discussion…………………………………………………………………………..………17-23

Tables and Figures

Table 1: Participant Characteristics…………………………………………………… ..24-26

Table 2: Inflammatory Variables………………………………………………………....27-28

Table 3: Cognitive performance…………………………………………………….……29-31

Table 4: Nonsignificant Correlations Between IL-10 and Cognitive Tests…………..32-33

Figure 1: Nonsignificant Scatter plots of Montreal Cognitive Assessment Score and Interleukin-10 ………….……34

Figure 2: Nonsignificant Scatter plots of Color Word Interference Test – Inhibition/Switching Scaled Score and Interleukin-10 Variables…35

Figure 3: Nonsignificant Scatter plots of Tower of London Test – Total Rule Violations Cumulative Percentile Rank and Interleukin-10…..36

Figure 4: Trails difference…..………………………………………………………………...37

References……………………………………………………………………………….…38-44

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