Dorsal anterior cingulate and anterior insula encode a novel subjective value prediction error signal during effort-based decision-making Öffentlichkeit
Arulpragasam, Amanda (Fall 2017)
Published
Abstract
Integrating cost and benefit information is crucial for optimal decision-making. The dorsal anterior cingulate cortex (dACC) and anterior insula (AI) have been implicated in effort-based decision-making, but it remains unknown whether computations performed by these regions are involved in the evaluation of effort, reward, or their integration. To this end, 28 healthy participants completed a novel sequential effort-based decision-making task while undergoing functional magnetic resonance imaging (fMRI). This task presented trial-wise information about effort costs and reward magnitude separately throughout time, allowing us to model distinct effort-based choice computations. We observed a role for dACC in subjective value discounting and choice difficulty, but not for effort cost encoding. Notably, we observed a novel role for dACC in the generation of subjective value prediction error signals as choice-relevant information unfolded. We also observed co-activation of AI with dACC as part of a network unique to this prediction error. These data help elucidate multiple computations performed by dACC during effort-based decision-making as well as provide evidence for the recruitment of AI to aid in prediction error signaling .
Table of Contents
Introduction 1
Results 3
Behavioral Results 3
Computational Model 4
Neuroimaging Results 5
Subjective Value Encoding 5
Subjective Value Prediction Error 6
Spatial Specificity 7
Expectation Formation 8
Discussion 8
Limitations 11
Conclusion 12
Methods 13
Participants 13
Procedure 13
Image Acquisition 16
Behavioral Analysis 16
Subjective Value Models 16
Subjective Value Prediction Error 20
fMRI Analysis 21
References 23
Figures 32
Tables 36
Supplemental Materials 37
Supplemental Methods 37
Indifference Point Estimation and Choice Difficulty Model 37
Subjective Value Prediction Error 38
Binned Trial Analysis 38
Supplemental Results 39
Choice Difficulty 39
Subjective Value Extended 40
Supplemental References 42
Supplemental Figures 44
Supplemental Tables 47
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