Inflammatory-related Exposures and the Presence of Immune Cells in the Tumor Microenvironment of Black Women with Ovarian Cancer Público

Abstract

Background:

 Inflammatory-related external exposures (e.g., BMI, smoking and medication use) have been hypothesized to mediate the immune response and further influence tumor microenvironment in ovarian cancer. However, data to support this has not been established. Moreover, among all racial and ethnic groups, Black women are shown to have the worst prognosis and survival in ovarian cancers.

Method:

The current study investigated the influence of various inflammatory-related exposures on the presence of immune markers in tumor and overall tumor microenvironment (tumor + stroma)[JCE1] . A total of 338 black women with high-grade serous ovarian cancer (HGSOC), the most common histotype of epithelial ovarian cancer (65-70%) were included in this study. CD3+, CD3+FoxP3+ and CD3+CD8+ are measured both in tumor and in total (tumor + stroma) with ≥ 1% as present, < 1% as absent. The odds ratios for the association of each immune marker and inflammatory-related exposures were calculated.

Results:

Aspirin use was found to be associated with an increased level of CD3+ both tumor tissue and in total with an odds ratio 2.30 (95% CI: 1.16, 4.56) in total and an odds ratio of 2.20 (1.13, 4.30) in tumor only for ever users versus never users. Non-aspirin NSAID use was inversely associated with CD3+FoxP3+ only in tumor with an odds ratio 0.17 (CI: 0.04, 0.73). Suggestive inverse relationships were found among light smokers with CD3+ and CD3+ CD8+ expression both in total and in tumor. Talc use on genital area was found to be associated with increased CD3+ presence both in total and in tumor.

Conclusion:

Our results show that inflammatory-related exposures could have influence on tumor microenvironment, especially on immune markers in Black women with ovarian cancer.  [JCE1]You did not do analysis within the stroma. You only had tumor and total (tumor + stroma). You should remove references to stroma throughout.

Table of Contents

Table of Contents

Background. - 1 -

Inflammation-Related Exposures Contribute to Ovarian Cancer risk and Survival. - 2 -

Tumor Markers and the Ovarian Tumor Microenvironment - 7 -

Differences in ovarian cancer survival within racial and ethnic groups. - 8 -

Preliminary Data. - 9 -

Method. - 10 -

Data Source. - 10 -

Study Population. - 10 -

Exposure Classification. - 11 -

Immune Markers: Outcome Classification. - 12 -

Statistical Analysis. - 13 -

Results. - 13 -

Discussion. - 15 -

Tables. - 21 -

Reference. - 29 -

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Subfield / Discipline	Epidemiology - MPH & MSPH
Degree	M.P.H.
Submission	Master's Thesis
Language	English
Research Field	Health Sciences, Immunology Health Sciences, Oncology
Palabra Clave	Black Women Ovarian Cancer Immune Marker Inflammation
Committee Chair / Thesis Advisor	Schildkraut, Joellen Martha, Emory University

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