Movement Abnormalities in Youth at Clinical and Genetic Risk for Psychosis Public

Abstract

The link between movement abnormalities and psychotic disorders is presumed to reflect a common neural mechanism that influences both motor function and vulnerability to psychosis. However, it remains unclear how these movement abnormalities manifest in indivduals at clinical or genetic risk for schizophrenia-spectrum disorders. Examining movemen abnormalities in at-risk populations enhances the potential to identify neural substrates that may be linked to etiology. The present study examined the nature and occurrence of movement abnormalties, as well as their associaton with prodromal symptoms, in youth at clinical risk for psychosis and patients with 22q11.2 deletion syndrome. The Structured Interview for Prodromal Symptoms (Miller et al., 2002) and the Dyskinesia Identification System (Kalachnik & Sprague, 1993) were used to assess prodromal symptoms and movement abnormalities in normal controls (NC; n=27), youth at clinical-risk (Prodromal; n=49), 22q11.2 deletion syndrome patients (22q11DS; n=31), and psyhiatric controls (OPD; n=30). Results showed that the 22q11 DS and Prodromal groups had elevated rates of movement abnormalities compared to the NC and OPD groups, with 22q11 DS exhibiting the most severe movement abnormalities. Results also revealed differing associations between movement abnormalities and prodromal symptoms. In the Prodromal group, movement abnormalities were positively correlated with negative symptoms, while in the 22q11 DS group movement abnormalties were positively correlated with positive symptoms. These findings suggest that movement abnormalities are elevated in at-risk populations and that both unique and shared neural mechanisms give rise to a partially overlapping phenotype.

Table of Contents

Introduction...2

Method...13

Results...17

Discussion...20

References...30

Tables...42

Figures...47

About this Honors Thesis

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School	Emory College
Department	Psychology
Degree	BA
Submission	Honors Thesis
Language	English
Research Field	Psychology, Clinical
Mot-clé	movement abnormalities psychosis
Committee Chair / Thesis Advisor	Walker, Elaine, Emory University
Committee Members	Cubells, Joseph F, Emory University Lilienfeld, Scott O, Emory University

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