Parceling dorsal and medial frontal cortex in humans and chimpanzees with structural connectivity Pubblico
Singletary, Nicholas Martin (2016)
Published
Abstract
The dorsomedial prefrontal cortex is a region of cerebral cortex that shows functional activation during social cognitive tasks in humans and chimpanzees. However, the nature of the anatomical regions that support these functional activations is unknown, and this region's structural connections to other brain regions is debated. Therefore, we propose a new method for parceling cortex based on searching for borders of connectivity. Using this approach, we discovered three apparently homologous regions in humans and chimpanzees within the vicinity of dmPFC: dorsomedial rim, frontal pole, and cingulate cortex. The parcels that resulted from these borders conform to the borders of dmPFC as identified by functional activation studies and meta-analyses of brain regions involved in social cognition. These structural connectivity maps provide another means for noninvasive anatomical mapping of the cerebral cortex.
Table of Contents
Introduction. 1
Methods. 12
Subjects and scanning. 12
Analysis. 13
Results. 19
Identification of connectivity-based secondary ROIs. 19
Identifying connectivity borders. 20
Connectivity patterns of parcels. 28
Comparison of connectivity borders to myeloarchitectonic borders. 34
Discussion. 38
Location of borders. 38
Comparing parcels. 40
Unexpected connections. 42
Further study. 45
Possible Sex Differences. 46
Applications. 47
Conclusion. 49
References. 50
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