Pruritus: the skin equivalent of pain as measured by health utilities 公开
Kini, Seema Panduranga (2011)
Abstract
Abstract
Objective : To compare the quality of life impact
of chronic pruritus to that of chronic pain using
directly elicited health utilities
Design: Cross-sectional study
Setting: Convenience sample of patients attending the Emory
Dermatology Clinic, Emory Spine
Center, and Emory Center for Pain Management.
Participants: Adult men and women (≥18 years)
experiencing chronic pain or pruritus for a
minimum of 6 weeks
Main Outcome Measure: The mean utility score of subjects
with chronic pruritus was
compared to that of subjects with chronic pain. A regression
analysis was performed to
determine the impact of the primary predictor variable, symptom
type, on the primary outcome
variable, mean utility score (a measurement for quality of life
impact)
Results: 73 subjects with chronic pruritus and 138 subjects
with chronic pain were recruited.
Mean (SD) utility among patients with pruritus was 0.874 (0.27)
compared to 0.767 (0.31) for
subjects with pain (p<0.001). After controlling for symptom
severity, duration, and demographic
factors, only symptom severity (-0.03, p=0.048) and single marital
status (-0.12, p= 0.02) and not
symptom type (0.05, p= 0.43) remained a significant predictor of
mean utility score.
Conclusions : Chronic pruritus has substantial
quality of life impact which may be comparable to
that of pain. Symptom severity and support networks are important
factors in determining the
extent of quality of life impact. Addressing support networks in
addition to developing new
therapies may improve the quality of life of itchy patients.
Table of Contents
I. Introduction……………………………………………………………………………………………….1
II. Background………………………………………………………………………………………………..2
IIa. Pruritus………………………………………………………………………………………………..2
IIb. Pruritus and pain………………………………………………………………………………….3
IIc. Health-related quality of life………………………………………………………………..4
IId. Health utilities in dermatology…………………………………………………………….4
III. Methods…………………………………………………………………………………………………….6
IIIa. Survey variables……………………………………………………………………………………8
IIIb. Statistical Analyses……………………………………………………………………………….8
IIIc. Power Analysis……………………………………………………………………………………..8
IV. Results………………………………………………………………………………………………………..10
IVa. Demographics and Characteristics of Pain and Pruritus Cohorts………….10
IVb. Results of Multivariate Regression Model……………………………………………11
V. Discussion……………………………………………………………………………………………………12
Va. Limitations…………………………………………………………………………………………….13
Vb. Conclusions…………………………………………………………………………………………..15
VI. References…………………………………………………………………………………………………16
VII. Tables…………………………………………………………………………………………………………18
VIII. Appendix…………………………………………………………………………………………………..20
About this Master's Thesis
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