The effect of maternal alcohol consumption on the diagnosis of reactive airway disease in early childhood: Data from the Fetal Growth and Development Study (FGDS) and the Follow-Up of Development and Growth Experiences Study (FUDGE) 公开

Pruitt, Shannon (2017)

Permanent URL: https://etd.library.emory.edu/concern/etds/2514nm312?locale=zh
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Abstract

Asthma is a major cause of morbidity and hospitalization in young children. However, little is known about the etiology of asthma. Alcohol consumption during pregnancy could be a factor involved in the development of childhood asthma. The aims of this analysis were to examine the relationship between differing levels of maternal alcohol consumption and diagnosis of asthma during early childhood. Data for this analysis were obtained from the Fetal Growth and Development Study (FGDS) and the Follow-up of Development and Growth Experiences Study (FUDGE). FGDS was a case control study of risk factors for infants born small-for-gestational age in two metropolitan Atlanta hospitals in 1993 and 1994. FUDGE was a follow-up to FGDS and included a proportion of participants at age four and a half years. Multivariable logistic regression was used to examine the effect of any alcohol consumption, moderate alcohol consumption, heavy alcohol consumption, and binge drinking on the development of childhood reactive airway disease. In unadjusted models, differing levels of maternal alcohol use showed no association with diagnosis of reactive airway disease unaffected by adjustment. While unadjusted models showed an inverse association, this effect was not present after controlling for education, small for gestational age, income, and smoking. Although imprecise, these data provide evidence that prenatal exposure to alcohol is not associated with diagnosis of reactive airway disease. These findings suggest that future research should examine other factors outside of maternal alcohol consumption to understand the large prevalence of asthmatic disease in children.

Table of Contents

CHAPTER 1: BACKGROUND AND LITERATURE REVIEW................... 1

Burden of Disease:.................................................................... 1

Epidemiology............................................................................ 2

Biological Effects....................................................................... 3

Alcohol.................................................................................... 4

CHAPTER II: MANUSCRIPT......................................................... 6

INTRODUCTION........................................................................ 6

METHODS................................................................................ 7

Data Sources:.......................................................................... 7

Questionnaire:......................................................................... 9

Analysis:................................................................................. 9

RESULTS................................................................................ 10

DISCUSSION:......................................................................... 12

REFERENCES.......................................................................... 15

TABLES.................................................................................. 18

CHAPTER III: SUMMARY, PUBLIC HEALTH IMPLICATIONS, POSSIBLE FUTURE DIRECTIONS........................ 20

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