Hepatocyte Growth Factor and Hepatocyte Growth Factor Activator Release of Fibroadipogenic Progenitors in Uninjured Pharyngeal Muscles Público

Abstract

Satellite cells (SCs) are skeletal stem cells that are quiescent in homeostatic adult muscles but are highly important for muscle regeneration upon injury. In pharyngeal muscles, SCs actively proliferate, differentiate, and fuse into muscle fibers even in an absence of injury, though the cause is unknown. Here, we concluded that pharyngeal SCs do not show a significant increase in proliferation and differentiation from limb SCs in vitro, indicating that external niche contributes to the activation of pharyngeal SCs more than their intrinsic abilities. In the pharyngeal environment, Fibroadipogenic progenitor cells contribute hepatocyte growth factors (HGF) and HGF activating enzymes to activate SCs. In this study, we show the possible explanation for the unique activity of pharyngeal SCs and how these distinct characteristics may contribute to their different susceptibilities to diseases like oculopharyngeal muscular dystrophy.

Table of Contents

Introduction……………………………………………………………………………………….....1

Materials and Methods………………………………………………………………………….….2

Results………………………………………………………………………………………….....…..3

Figure 1: The average area of satellite cells…………………………………………….....….5

Figure 2: Pharyngeal and limb MPCs proliferate and differentiate at similar levels…6

Figure 3: HGF concentration is elevated in conditioned media of FAPs…………………9

Discussion……………………………………………………………………………………....…..11

References………………………………………………………………………………………......14

About this Honors Thesis

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School	Emory College
Department	Biology
Degree	B.S.
Submission	Honors Thesis
Language	English
Research Field	Biology, Cell
Palabra Clave	Satellite cells
Committee Chair / Thesis Advisor	Choo, Hyojung, Emory University
Committee Members	Beck, Christopher, Emory University Kelly, William, Emory University

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