Abstract
INTRODUCTION: Salivary Gland Carcinoma (SGC) is a rare type of
cancer affecting the parotid, submandibular, sublingual, and minor
glands. There are few epidemiologic studies focusing on the
malignancy among pediatric patients. The purpose of this study was
to examine SGC incidence and survival in persons under 20 years of
age. METHODS: Eligible cases (n= 433) were selected from the
Surveillance, Epidemiology, and End Results (SEER) registries for
the period 1973- 2013. Incidence of SGC was examined across
demographic groups and over time. Associations of age at diagnosis,
sex, race/ethnicity, year of diagnosis, histology, stage and site
with survival were analyzed by Kaplan Meier curves and Cox
proportional hazards models. RESULTS: Most patients were between
10-19 years old (89.4%) and Non-Hispanic Whites (58.9%). The most
common SGC site was the parotid gland (86.6%), most common
histology was mucoepidermoid neoplasm (43%) and the majority of
tumors were localized (69.3%). Females and older children had a
significantly higher age-adjusted incidence rate compared to males
or children 0-9 years of age, respectively, but there was no
difference by race. A diagnosis within the last 10 years, having a
rare histological type, and a distant stage were associated with
survival, while survival did not differ by age, sex, and primary
site. CONCLUSIONS: While females and older children had higher
incidence rates, they do not have significantly different survival
outcomes. Histological type and stage could be useful prognostic
factors, and further studies are needed to elucidate these
differences.
Table of Contents
Background.............. 1 Methods................. 5
Results................. 8 Discussion.............. 10
References.............. 13 Tables and Figures...... 15
About this Master's Thesis
Rights statement
- Permission granted by the author to include this thesis or dissertation in this repository. All rights reserved by the author. Please contact the author for information regarding the reproduction and use of this thesis or dissertation.
| School |
|
|---|
| Department |
|
|---|
| Degree |
|
|---|
| Submission |
|
|---|
| Language |
|
|---|
| Research Field |
|
|---|
| 关键词 |
|
|---|
| Committee Chair / Thesis Advisor |
|
|---|
| Partnering Agencies |
|
|---|