Pediatric Salivary Gland Carcinoma: Incidence and survival trends based on 1973-2013 SEER data 公开

Abstract

INTRODUCTION: Salivary Gland Carcinoma (SGC) is a rare type of cancer affecting the parotid, submandibular, sublingual, and minor glands. There are few epidemiologic studies focusing on the malignancy among pediatric patients. The purpose of this study was to examine SGC incidence and survival in persons under 20 years of age. METHODS: Eligible cases (n= 433) were selected from the Surveillance, Epidemiology, and End Results (SEER) registries for the period 1973- 2013. Incidence of SGC was examined across demographic groups and over time. Associations of age at diagnosis, sex, race/ethnicity, year of diagnosis, histology, stage and site with survival were analyzed by Kaplan Meier curves and Cox proportional hazards models. RESULTS: Most patients were between 10-19 years old (89.4%) and Non-Hispanic Whites (58.9%). The most common SGC site was the parotid gland (86.6%), most common histology was mucoepidermoid neoplasm (43%) and the majority of tumors were localized (69.3%). Females and older children had a significantly higher age-adjusted incidence rate compared to males or children 0-9 years of age, respectively, but there was no difference by race. A diagnosis within the last 10 years, having a rare histological type, and a distant stage were associated with survival, while survival did not differ by age, sex, and primary site. CONCLUSIONS: While females and older children had higher incidence rates, they do not have significantly different survival outcomes. Histological type and stage could be useful prognostic factors, and further studies are needed to elucidate these differences.

Table of Contents

Background.............. 1 Methods................. 5 Results................. 8 Discussion.............. 10 References.............. 13 Tables and Figures...... 15

About this Master's Thesis

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School	Rollins School of Public Health
Department	Epidemiology
Degree	MPH
Submission	Master's Thesis
Language	English
Research field	Health Sciences, Public Health Health Sciences, Oncology Health Sciences, Epidemiology
关键词	salivary gland epidemiology survival pediatric SEER cancer incidence
Committee Chair / Thesis Advisor	Goodman, Michael, Emory University
Partnering Agencies	Does not apply (no collaborating organization)

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